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Peptide record

TPDB48895

Antifungal standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB48895
Antifungal
Anti-infective peptides
AFP-GFuse
standard
No
A 44-aa standard natural antifungal peptide sequence curated from AFP-GFuse, with an available 3D structural model.
Sequence
GIINTLQKYYCRVRGAICHPVFCPRRYKQIGTCGLPGTKCCKKP
Physicochemical Analysis
C219H358N66O54S6
DEMSW
C
4972.02
9.97
10
0
13
+9
5.22
-0.273
68.64
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
97.45
15
Residue Composition
number
1
A
4
R
1
N
0
D
6
C
0
E
2
Q
5
G
1
H
4
I
2
L
5
K
0
M
1
F
4
P
0
S
3
T
0
W
3
Y
2
V
Amino Acid Distribution
A: 1 R: 4 N: 1 D: 0 C: 6 E: 0 Q: 2 G: 5 H: 1 I: 4 L: 2 K: 5 M: 0 F: 1 P: 4 S: 0 T: 3 W: 0 Y: 3 V: 2
Chemical Descriptors
44
C219H358N66O54S6
4972.02
9.97
+9
5.22
-0.273
Evidence Records 1 records
Evidence 1 Activity

Activity

Antifungal

Source & Reference

NA

Other

active against both E. coli (MBC 0.1 ug/ml) and S. aureus (MBC 0.78 ug/ml) better than either hBD2 or hBD3. Also active against K. pneumoniae CF1 ESBL (MBC 0.39-3.13 ug/ml), P. aeruginosa (MBC 1.56 ug/ml), E. faecalis ATCC 51299 (MBC 0.78 ug/ml) anti-VRE, E. faecium 4 strains (MBC 0.78-1.56 ug/ml), S. aureus MRSA (MBC 0.78 ug/ml), and C. albicans 5 strains (MBC 12.5-50 ug/ml). Anaerobic bacteria: B. fragilis ATCC 25285 (MBC 6.25 ug/ml), C.perfringens ATCC 13124 (MBC >100 ug/ml), P. anaerobius ATCC 27337 (MBC 50 ug/ml), P. acnes ATCC 6919 (MBC 1.56 ug/ml), and P. oralis ATCC 33321 (MBC > 100 ug/ml).