TPDB

3D PDB MODEL

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TPDB ID TPDB48731

Peptide_Name

PhrCACET1 WSW

Activity

Blood-Brain Barrier Quorum sensing

Activity_category_statistics

Anti-infective peptides Delivery and barrier-penetrating peptides

Database_Source

B3Pred BBPpredict Peptipedia EnsembleQS QSPred-FL

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (Blood-Brain Barrier and Quorum sensing) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.

Sequence

SYPGWSW

FASTA

>TPDB48731|Blood-Brain Barrier;Quorum sensing|length=7
SYPGWSW

Formula C44H51N9O11

Absent Amino Acids ARNDCEQHILKMFTV

Common Amino Acids SW

Mass 881.94

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -3.92

Hydrophobicity -0.957

Aliphatic Index 0.00

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 12490

Absorbance 280nm 1416.19

Polar Residues 3

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

2

S

0

T

2

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 2 T: 0 W: 2 Y: 1 V: 0

Length

7

Formula

C44H51N9O11

Mass

881.94

PI

5.94

Net Charge

-0

Boman Index

-3.92

Hydrophobicity

-0.957

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Ser-Tyr-Pro-Gly-Trp-Ser-Trp

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Assay & Model

Animal Model Origin/Source

Source & Reference

Database Source NA

Source B3Pdb

Other

BBB Action quorum sensing peptide

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.02 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 84.90%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 15.10%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00133 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.03553 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bacterial

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous