TPDB

3D PDB MODEL

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TPDB ID TPDB48719

Peptide_Name

PhrANTH2

Activity

Blood-Brain Barrier Quorum sensing

Activity_category_statistics

Anti-infective peptides Delivery and barrier-penetrating peptides

Database_Source

B3Pred BBPpredict Peptipedia EnsembleQS QSPred-FL

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (Blood-Brain Barrier and Quorum sensing) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.

Sequence

SKDYN

FASTA

>TPDB48719|Blood-Brain Barrier;Quorum sensing|length=5
SKDYN

Formula C26H39N7O11

Absent Amino Acids ARCEQGHILMFPTWV

Common Amino Acids NDKSY

Mass 625.64

PI 6.68

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -0

Boman Index 1.83

Hydrophobicity -2.600

Aliphatic Index 0.00

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 238.16

Polar Residues 3

number

0

A

0

R

1

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

1

K

0

M

0

F

0

P

1

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0

Length

5

Formula

C26H39N7O11

Mass

625.64

PI

6.68

Net Charge

-0

Boman Index

1.83

Hydrophobicity

-2.600

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Ser-Lys-Asp-Tyr-Asn

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.05 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 79.40%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 20.60%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00018 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00659 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous