TPDB

3D PDB MODEL

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TPDB ID TPDB48641

Peptide_Name

BIP-2

Activity

Blood-Brain Barrier Quorum sensing

Activity_category_statistics

Anti-infective peptides Delivery and barrier-penetrating peptides

Database_Source

B3Pred BBPpredict Peptipedia EnsembleQS QSPred-FL

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Blood-Brain Barrier and Quorum sensing) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.

Sequence

GLWEDLLYNINRYAHYIT

FASTA

>TPDB48641|Blood-Brain Barrier;Quorum sensing|length=18
GLWEDLLYNINRYAHYIT

Formula C106H152N26O29

Absent Amino Acids CQKMFPSV

Common Amino Acids LY

Mass 2254.53

PI 5.22

Basic Residues 2

Acidic Residues 2

Hydrophobic Residues 10

Net Charge -1

Boman Index -1.13

Hydrophobicity -0.300

Aliphatic Index 113.89

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 9970

Absorbance 280nm 442.22

Polar Residues 6

number

1

A

1

R

2

N

1

D

0

C

1

E

0

Q

1

G

1

H

2

I

3

L

0

K

0

M

0

F

0

P

0

S

1

T

1

W

3

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 2 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 1 I: 2 L: 3 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 3 V: 0

Length

18

Formula

C106H152N26O29

Mass

2254.53

PI

5.22

Net Charge

-1

Boman Index

-1.13

Hydrophobicity

-0.300

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Gly-Leu-Trp-Glu-Asp-Leu-Leu-Tyr-Asn-Ile-Asn-Arg-Tyr-Ala-His-Tyr-Ile-Thr

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.06 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 76.90%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 23.10%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00035 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01267 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous