TPDB

3D PDB MODEL

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TPDB ID TPDB48534

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antiparasitic

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (ACE inhibitors and Antiparasitic) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

LFR

FASTA

>TPDB48534|ACE inhibitors;Antiparasitic|length=3
LFR

Formula C21H34N6O4

Absent Amino Acids ANDCEQGHIKMPSTWYV

Common Amino Acids RLF

Mass 434.54

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index -0.88

Hydrophobicity 0.700

Aliphatic Index 130.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

3

Formula

C21H34N6O4

Mass

434.54

PI

11.05

Net Charge

+1

Boman Index

-0.88

Hydrophobicity

0.700

Chemical_Mass

434.5311

Monoisotopic_Mass

434.2634

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 31.80 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Liu R., Zhu Y., Chen J., Wu H., Shi L., Wang X., Wang L.

Title

Characterization of ACE inhibitory peptides from Mactra veneriformis hydrolysate by nano-liquid chromatography electrospray ionization mass spectrometry (Nano-LC-ESI-MS) and molecular docking. Mar. Drugs, 12, 3917-3928, 2014

Year 2014

Literature Source Journal

Other

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C21H34N6O4/c1-13(2)11-15(22)18(28)27-17(12-14-7-4-3-5-8-14)19(29)26-16(20(30)31)9-6-10-25-21(23)24/h3-5,7-8,13,15-17H,6,9-12,22H2,1-2H3,(H,26,29)(H,27,28)(H,30,31)(H4,23,24,25)/t15-,16-,17-/m0/s1 InChIKey: GCXGCIYIHXSKAY-ULQDDVLXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

3