TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB48497

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antiparasitic iDPPIV

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides

Database_Source

Peptipedia iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (Antiparasitic and iDPPIV) peptide sequence curated from Peptipedia and iDPPIV, with an available 3D structural model.

Sequence

FA

FASTA

>TPDB48497|Antiparasitic;iDPPIV|length=2
FA

Formula C12H16N2O3

Absent Amino Acids RNDCEQGHILKMPSTWYV

Common Amino Acids AF

Mass 236.27

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -1.30

Hydrophobicity 2.300

Aliphatic Index 50.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

2

Formula

C12H16N2O3

Mass

236.27

PI

6.02

Net Charge

-0

Boman Index

-1.30

Hydrophobicity

2.300

Chemical_Mass

236.2664

Monoisotopic_Mass

236.1157

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 0.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Bella A. M., Erickson R. H. Jr., Kim Y. S.

Title

Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV: kinetic properties and substrate specificities of the purified enzyme. Arch. Biochem. Biophys. 218 (1), 156-162 (1982)

Year 1982

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C12H16N2O3/c1-8(12(16)17)14-11(15)10(13)7-9-5-3-2-4-6-9/h2-6,8,10H,7,13H2,1H3,(H,14,15)(H,16,17)/t8-,10-/m0/s1 InChIKey=MIDZLCFIAINOQN-WPRPVWTQSA-N Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BindingDB database, the ChEMBL database, the PubChem database Antimicrobial peptide according to the ParaPep database Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9500)

Number_of_Residues

2