TPDB

3D PDB MODEL

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TPDB ID TPDB48461

Peptide_Name

Corticoliberin Corticotropin-releas

Activity

Antiparasitic Blood-Brain Barrier Neuropeptide

Activity_category_statistics

Anti-infective peptides Delivery and barrier-penetrating peptides Neuroactive peptides

Database_Source

i2APP Peptipedia BBPpredict

Sequence_Type

standard

Has_Modification No

Description A 41-aa standard natural multi-activity (Antiparasitic, Blood-Brain Barrier, and Neuropeptide) peptide sequence curated from i2APP, Peptipedia, and BBPpredict, with an available 3D structural model.

Sequence

SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII

FASTA

>TPDB48461|Antiparasitic;Blood-Brain Barrier;Neuropeptide|length=41
SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII

Formula C208H343N59O64S2

Absent Amino Acids CGWY

Common Amino Acids L

Mass 4758.49

PI 4.91

Basic Residues 6

Acidic Residues 7

Hydrophobic Residues 18

Net Charge -3

Boman Index 15.23

Hydrophobicity -0.256

Aliphatic Index 111.95

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 8

number

4

A

3

R

1

N

1

D

0

C

6

E

3

Q

0

G

2

H

3

I

7

L

1

K

2

M

1

F

2

P

3

S

1

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 4 R: 3 N: 1 D: 1 C: 0 E: 6 Q: 3 G: 0 H: 2 I: 3 L: 7 K: 1 M: 2 F: 1 P: 2 S: 3 T: 1 W: 0 Y: 0 V: 1

Length

41

Formula

C208H343N59O64S2

Mass

4758.49

PI

4.91

Net Charge

-3

Boman Index

15.23

Hydrophobicity

-0.256

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0002236 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,mouse,rat

In Vivo Mode of Delivery Intravenous

Transport Type Saturable

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Sauvagine/corticotropin-releasing factor/urotensin I

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Corticotropin-releasing factor receptor 1 Corticotropin-releasing factor receptor 2

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Sauvagine/corticotropin-releasing factor/urotensin I

Receptor Lengths 444 411

Receptor Ligands NP09856 NP09913 NP09856 NP09913 NP09918 NP09922

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Corticotropin-releasing factor receptor 1 Corticotropin-releasing factor receptor 2

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Sauvagine/corticotropin-releasing factor/urotensin I

Receptor Lengths 415 411

Receptor Ligands NP09857 NP09914 NP09857 NP09914 NP09919 NP09923

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Sauvagine/corticotropin-releasing factor/urotensin I

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Corticotropin-releasing factor receptor 1 Corticotropin-releasing factor receptor 2

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Sauvagine/corticotropin-releasing factor/urotensin I

Receptor Lengths 415 411

Receptor Ligands NP09859 NP09915 NP09871 NP09862 NP09863 NP09859 NP09915 NP09920 NP09871 NP09916 NP09917 NP09862 NP09863

Family

Sauvagine/corticotropin-releasing factor/urotensin I

In_Vivo_Mode_of_Delivery

Intravenous

Receptor_Lengths

444 411 415

Receptor_Ligands

NP09856 NP09913 NP09918 NP09922 NP09857 NP09914 NP09919 NP09923 NP09859 NP09915 NP09871 NP09862 NP09863 NP09920 NP09916 NP09917