TPDB

3D PDB MODEL

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TPDB ID TPDB48460

Peptide_Name

Urocortin

Activity

Antiparasitic Blood-Brain Barrier Neuropeptide

Activity_category_statistics

Anti-infective peptides Delivery and barrier-penetrating peptides Neuroactive peptides

Database_Source

i2APP Peptipedia BBPpredict

Sequence_Type

standard

Has_Modification No

Description A 40-aa standard natural multi-activity (Antiparasitic, Blood-Brain Barrier, and Neuropeptide) peptide sequence curated from i2APP, Peptipedia, and BBPpredict, with an available 3D structural model.

Sequence

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV

FASTA

>TPDB48460|Antiparasitic;Blood-Brain Barrier;Neuropeptide|length=40
DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV

Formula C206H337N61O65

Absent Amino Acids CGKMWY

Common Amino Acids L

Mass 4708.31

PI 4.81

Basic Residues 6

Acidic Residues 7

Hydrophobic Residues 15

Net Charge -2

Boman Index 12.48

Hydrophobicity -0.460

Aliphatic Index 109.75

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 10

number

2

A

5

R

1

N

4

D

0

C

3

E

3

Q

0

G

1

H

3

I

7

L

0

K

0

M

2

F

2

P

3

S

3

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 2 R: 5 N: 1 D: 4 C: 0 E: 3 Q: 3 G: 0 H: 1 I: 3 L: 7 K: 0 M: 0 F: 2 P: 2 S: 3 T: 3 W: 0 Y: 0 V: 1

Length

40

Formula

C206H337N61O65

Mass

4708.31

PI

4.81

Net Charge

-2

Boman Index

12.48

Hydrophobicity

-0.460

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Corticotropin-releasing factor receptor 1 Corticotropin-releasing factor receptor 2

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Sauvagine/corticotropin-releasing factor/urotensin I

Receptor Lengths 415 411

Receptor Ligands NP09857 NP09914 NP09857 NP09914 NP09919 NP09923

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Corticotropin-releasing factor receptor 1 Corticotropin-releasing factor receptor 2

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Sauvagine/corticotropin-releasing factor/urotensin I

Receptor Lengths 415 411

Receptor Ligands NP09859 NP09915 NP09871 NP09862 NP09863 NP09859 NP09915 NP09920 NP09871 NP09916 NP09917 NP09862 NP09863

Family

Sauvagine/corticotropin-releasing factor/urotensin I

Receptor_Lengths

415 411

Receptor_Ligands

NP09857 NP09914 NP09919 NP09923 NP09859 NP09915 NP09871 NP09862 NP09863 NP09920 NP09916 NP09917