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Peptide record

TPDB48398

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB48398
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.
Sequence
VSGAGRY
Physicochemical Analysis
C30H48N10O10
NDCEQHILKMFPTW
G
708.77
9.88
1
0
3
+1
-0.08
-0.200
55.71
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
210.22
2
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
7
C30H48N10O10
708.77
9.88
+1
-0.08
-0.200
708.7612
708.3544
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
8.64 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Priyanto A. D., Doerksen R. J., Chang C.-I., Sung W.-C., Widjanarko S. B., Kusnadi J., Lin Y.-C., Wang T.-C., Hsu J.-L.
Screening, discovery, and characterization of angiotensin-I converting enzyme inhibitory peptides derived from proteolytic hydrolysate of bitter melon seed proteins. J. Proteom., 128, 424-435, 2015
2015
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C30H48N10O10/c1-15(2)24(31)28(48)40-21(14-41)26(46)36-12-22(43)37-16(3)25(45)35-13-23(44)38-19(5-4-10-34-30(32)33)27(47)39-20(29(49)50)11-17-6-8-18(42)9-7-17/h6-9,15-16,19-21,24,41-42H,4-5,10-14,31H2,1-3H3,(H,35,45)(H,36,46)(H,37,43)(H,38,44)(H,39,47)(H,40,48)(H,49,50)(H4,32,33,34)/t16-,19-,20-,21-,24-/m0/s1 InChIKey: CQBLVPOPZVSCAA-CYBFVLSLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
8.64 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Priyanto A. D., Doerksen R. J., Chang C.-I., Sung W.-C., Widjanarko S. B., Kusnadi J., Lin Y.-C., Wang T.-C., Hsu J.-L.
Screening, discovery, and characterization of angiotensin-I converting enzyme inhibitory peptides derived from proteolytic hydrolysate of bitter melon seed proteins. J. Proteom., 128, 424-435, 2015
2015
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C30H48N10O10/c1-15(2)24(31)28(48)40-21(14-41)26(46)36-12-22(43)37-16(3)25(45)35-13-23(44)38-19(5-4-10-34-30(32)33)27(47)39-20(29(49)50)11-17-6-8-18(42)9-7-17/h6-9,15-16,19-21,24,41-42H,4-5,10-14,31H2,1-3H3,(H,35,45)(H,36,46)(H,37,43)(H,38,44)(H,39,47)(H,40,48)(H,49,50)(H4,32,33,34)/t16-,19-,20-,21-,24-/m0/s1 InChIKey: CQBLVPOPZVSCAA-CYBFVLSLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
7