TPDB

3D PDB MODEL

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TPDB ID TPDB48389

Peptide_Name

ACE inhibitor Renin inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

LTFPG

FASTA

>TPDB48389|ACE inhibitors;Antihypertensive|length=5
LTFPG

Formula C26H39N5O7

Absent Amino Acids ARNDCEQHIKMSWYV

Common Amino Acids GLFPT

Mass 533.62

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -1.09

Hydrophobicity 0.780

Aliphatic Index 78.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

0

K

0

M

1

F

1

P

0

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

5

Formula

C26H39N5O7

Mass

533.62

PI

6.02

Net Charge

-0

Boman Index

-1.09

Hydrophobicity

0.780

Chemical_Mass

533.6156

Monoisotopic_Mass

533.2840

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Aluko R. E., Girgih A. T., He R., Malomo S., Li H., Offengenden M., Wu J.

Title

Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res. Int., 77, 10-16, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(O)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)O InChI=1S/C26H39N5O7/c1-15(2)12-18(27)23(35)30-22(16(3)32)25(37)29-19(13-17-8-5-4-6-9-17)26(38)31-11-7-10-20(31)24(36)28-14-21(33)34/h4-6,8-9,15-16,18-20,22,32H,7,10-14,27H2,1-3H3,(H,28,36)(H,29,37)(H,30,35)(H,33,34)/t16?,18-,19-,20-,22-/m0/s1 InChIKey: DHDNWIDWZYRTMI-UFLJCPFWSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 9119)

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Aluko R. E., Girgih A. T., He R., Malomo S., Li H., Offengenden M., Wu J.

Title

Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res. Int., 77, 10-16, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(O)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)O InChI=1S/C26H39N5O7/c1-15(2)12-18(27)23(35)30-22(16(3)32)25(37)29-19(13-17-8-5-4-6-9-17)26(38)31-11-7-10-20(31)24(36)28-14-21(33)34/h4-6,8-9,15-16,18-20,22,32H,7,10-14,27H2,1-3H3,(H,28,36)(H,29,37)(H,30,35)(H,33,34)/t16?,18-,19-,20-,22-/m0/s1 InChIKey: DHDNWIDWZYRTMI-UFLJCPFWSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 9119)

Evidence 3 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007)

Detail Activity renin inhibitor

Activity Code ren

Source & Reference

Database Source NA

Authors Aluko R. E., Girgih A. T., He R., Malomo S., Li H., Offengenden M., Wu J.

Title

Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res. Int., 77, 10-16, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(O)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)O InChI=1S/C26H39N5O7/c1-15(2)12-18(27)23(35)30-22(16(3)32)25(37)29-19(13-17-8-5-4-6-9-17)26(38)31-11-7-10-20(31)24(36)28-14-21(33)34/h4-6,8-9,15-16,18-20,22,32H,7,10-14,27H2,1-3H3,(H,28,36)(H,29,37)(H,30,35)(H,33,34)/t16?,18-,19-,20-,22-/m0/s1 InChIKey: DHDNWIDWZYRTMI-UFLJCPFWSA-N Information concerning Renin is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: A01.007 Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 9118)

Number_of_Residues

5