Back to search

Peptide record

TPDB48388

ACE inhibitor ACE inhibitors Antihypertensive standard
7 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB48388
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.
Sequence
LSSGDVF
Physicochemical Analysis
C32H49N7O12
ARNCEQHIKMPTWY
S
723.78
3.10
0
1
3
-1
-0.12
0.757
97.14
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
1
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
7
C32H49N7O12
723.78
3.10
-1
-0.12
0.757
723.7692
723.3427
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Aluko R. E., Girgih A. T., He R., Malomo S., Li H., Offengenden M., Wu J.
Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res. Int., 77, 10-16, 2015
2015
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C32H49N7O12/c1-16(2)10-19(33)27(45)37-23(15-41)30(48)38-22(14-40)28(46)34-13-24(42)35-20(12-25(43)44)29(47)39-26(17(3)4)31(49)36-21(32(50)51)11-18-8-6-5-7-9-18/h5-9,16-17,19-23,26,40-41H,10-15,33H2,1-4H3,(H,34,46)(H,35,42)(H,36,49)(H,37,45)(H,38,48)(H,39,47)(H,43,44)(H,50,51)/t19-,20-,21-,22-,23-,26-/m0/s1 InChIKey: IQVQAQNMZKTFKA-DAESNONBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Aluko R. E., Girgih A. T., He R., Malomo S., Li H., Offengenden M., Wu J.
Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res. Int., 77, 10-16, 2015
2015
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C32H49N7O12/c1-16(2)10-19(33)27(45)37-23(15-41)30(48)38-22(14-40)28(46)34-13-24(42)35-20(12-25(43)44)29(47)39-26(17(3)4)31(49)36-21(32(50)51)11-18-8-6-5-7-9-18/h5-9,16-17,19-23,26,40-41H,10-15,33H2,1-4H3,(H,34,46)(H,35,42)(H,36,49)(H,37,45)(H,38,48)(H,39,47)(H,43,44)(H,50,51)/t19-,20-,21-,22-,23-,26-/m0/s1 InChIKey: IQVQAQNMZKTFKA-DAESNONBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
7