TPDB

3D PDB MODEL

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TPDB ID TPDB48379

Peptide_Name

ACE inhibitor Renin inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

IFENLQN

FASTA

>TPDB48379|ACE inhibitors;Antihypertensive|length=7
IFENLQN

Formula C39H60N10O13

Absent Amino Acids ARDCGHKMPSTWYV

Common Amino Acids N

Mass 876.96

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index 1.44

Hydrophobicity -0.414

Aliphatic Index 111.43

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

0

A

0

R

2

N

0

D

0

C

1

E

1

Q

0

G

0

H

1

I

1

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 2 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C39H60N10O13

Mass

876.96

PI

3.29

Net Charge

-1

Boman Index

1.44

Hydrophobicity

-0.414

Chemical_Mass

876.9505

Monoisotopic_Mass

876.4327

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Aluko R. E., Girgih A. T., He R., Malomo S., Li H., Offengenden M., Wu J.

Title

Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res. Int., 77, 10-16, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(=O)N)CCC(=O)N)CC(C)C)CC(=O)N)CCC(=O)O)Cc1ccccc1)[C@H](CC)C InChI=1S/C39H60N10O13/c1-5-20(4)32(43)38(60)48-25(16-21-9-7-6-8-10-21)36(58)45-23(12-14-31(53)54)33(55)47-26(17-29(41)51)37(59)46-24(15-19(2)3)35(57)44-22(11-13-28(40)50)34(56)49-27(39(61)62)18-30(42)52/h6-10,19-20,22-27,32H,5,11-18,43H2,1-4H3,(H2,40,50)(H2,41,51)(H2,42,52)(H,44,57)(H,45,58)(H,46,59)(H,47,55)(H,48,60)(H,49,56)(H,53,54)(H,61,62)/t20-,22-,23-,24-,25-,26-,27-,32-/m0/s1 InChIKey: SVUIGSYSODPZLU-FWXRAREPSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 9123)

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Aluko R. E., Girgih A. T., He R., Malomo S., Li H., Offengenden M., Wu J.

Title

Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res. Int., 77, 10-16, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(=O)N)CCC(=O)N)CC(C)C)CC(=O)N)CCC(=O)O)Cc1ccccc1)[C@H](CC)C InChI=1S/C39H60N10O13/c1-5-20(4)32(43)38(60)48-25(16-21-9-7-6-8-10-21)36(58)45-23(12-14-31(53)54)33(55)47-26(17-29(41)51)37(59)46-24(15-19(2)3)35(57)44-22(11-13-28(40)50)34(56)49-27(39(61)62)18-30(42)52/h6-10,19-20,22-27,32H,5,11-18,43H2,1-4H3,(H2,40,50)(H2,41,51)(H2,42,52)(H,44,57)(H,45,58)(H,46,59)(H,47,55)(H,48,60)(H,49,56)(H,53,54)(H,61,62)/t20-,22-,23-,24-,25-,26-,27-,32-/m0/s1 InChIKey: SVUIGSYSODPZLU-FWXRAREPSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 9123)

Evidence 3 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007)

Detail Activity renin inhibitor

Activity Code ren

Source & Reference

Database Source NA

Authors Aluko R. E., Girgih A. T., He R., Malomo S., Li H., Offengenden M., Wu J.

Title

Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res. Int., 77, 10-16, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(=O)N)CCC(=O)N)CC(C)C)CC(=O)N)CCC(=O)O)Cc1ccccc1)[C@H](CC)C InChI=1S/C39H60N10O13/c1-5-20(4)32(43)38(60)48-25(16-21-9-7-6-8-10-21)36(58)45-23(12-14-31(53)54)33(55)47-26(17-29(41)51)37(59)46-24(15-19(2)3)35(57)44-22(11-13-28(40)50)34(56)49-27(39(61)62)18-30(42)52/h6-10,19-20,22-27,32H,5,11-18,43H2,1-4H3,(H2,40,50)(H2,41,51)(H2,42,52)(H,44,57)(H,45,58)(H,46,59)(H,47,55)(H,48,60)(H,49,56)(H,53,54)(H,61,62)/t20-,22-,23-,24-,25-,26-,27-,32-/m0/s1 InChIKey: SVUIGSYSODPZLU-FWXRAREPSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 9122)

Number_of_Residues

7