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Peptide record

TPDB48375

ACE inhibitor Renin inhibitor ACE inhibitors Antihypertensive standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB48375
ACE inhibitor Renin inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
FEGTVFENG
Physicochemical Analysis
C45H62N10O16
ARDCQHILKMPSWY
EGF
999.04
3.13
0
2
3
-2
2.43
-0.244
32.22
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
2
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
2
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
9
C45H62N10O16
999.04
3.13
-2
2.43
-0.244
999.0287
998.4330
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Aluko R. E., Girgih A. T., He R., Malomo S., Li H., Offengenden M., Wu J.
Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res. Int., 77, 10-16, 2015
2015
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)NCC(=O)N[C@@]([H])(C(O)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)O InChI=1S/C45H62N10O16/c1-23(2)37(55-45(71)38(24(3)56)54-33(58)21-48-40(66)28(14-16-34(59)60)50-39(65)27(46)18-25-10-6-4-7-11-25)44(70)53-30(19-26-12-8-5-9-13-26)43(69)51-29(15-17-35(61)62)42(68)52-31(20-32(47)57)41(67)49-22-36(63)64/h4-13,23-24,27-31,37-38,56H,14-22,46H2,1-3H3,(H2,47,57)(H,48,66)(H,49,67)(H,50,65)(H,51,69)(H,52,68)(H,53,70)(H,54,58)(H,55,71)(H,59,60)(H,61,62)(H,63,64)/t24?,27-,28-,29-,30-,31-,37-,38-/m0/s1 InChIKey: SPHVXKUUYHOXIF-CQWPEXIESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID (9126)
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Aluko R. E., Girgih A. T., He R., Malomo S., Li H., Offengenden M., Wu J.
Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res. Int., 77, 10-16, 2015
2015
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)NCC(=O)N[C@@]([H])(C(O)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)O InChI=1S/C45H62N10O16/c1-23(2)37(55-45(71)38(24(3)56)54-33(58)21-48-40(66)28(14-16-34(59)60)50-39(65)27(46)18-25-10-6-4-7-11-25)44(70)53-30(19-26-12-8-5-9-13-26)43(69)51-29(15-17-35(61)62)42(68)52-31(20-32(47)57)41(67)49-22-36(63)64/h4-13,23-24,27-31,37-38,56H,14-22,46H2,1-3H3,(H2,47,57)(H,48,66)(H,49,67)(H,50,65)(H,51,69)(H,52,68)(H,53,70)(H,54,58)(H,55,71)(H,59,60)(H,61,62)(H,63,64)/t24?,27-,28-,29-,30-,31-,37-,38-/m0/s1 InChIKey: SPHVXKUUYHOXIF-CQWPEXIESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID (9126)
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007)
renin inhibitor
ren

Source & Reference

NA
Aluko R. E., Girgih A. T., He R., Malomo S., Li H., Offengenden M., Wu J.
Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res. Int., 77, 10-16, 2015
2015
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)CNC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@@]([H])(N)Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)NCC(O)=O InChI=1S/C45H62N10O16/c1-23(2)37(55-45(71)38(24(3)56)54-33(58)21-48-40(66)28(14-16-34(59)60)50-39(65)27(46)18-25-10-6-4-7-11-25)44(70)53-30(19-26-12-8-5-9-13-26)43(69)51-29(15-17-35(61)62)42(68)52-31(20-32(47)57)41(67)49-22-36(63)64/h4-13,23-24,27-31,37-38,56H,14-22,46H2,1-3H3,(H2,47,57)(H,48,66)(H,49,67)(H,50,65)(H,51,69)(H,52,68)(H,53,70)(H,54,58)(H,55,71)(H,59,60)(H,61,62)(H,63,64)/t24-,27+,28+,29+,30+,31+,37+,38+/m1/s1 InChIKey=SPHVXKUUYHOXIF-XDZWWCOPSA-N Information concerning Renin is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: A01.007 Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 9125)
Additional Detail Fields 1 fields
9