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Peptide record

TPDB48281

ACE inhibitor from soybean ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB48281
ACE inhibitor from soybean
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia and AHTPDB, with an available 3D structural model.
Sequence
LNF
Physicochemical Analysis
C19H28N4O5
ARDCEQGHIKMPSTWYV
NLF
392.46
6.02
0
0
2
-0
-1.27
1.033
130.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C19H28N4O5
392.46
6.02
-0
-1.27
1.033
392.4483
392.2053
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
511.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Gu Y., Wu J.
LC–MS/MS coupled with QSAR modeling in characterising of angiotensin I-converting enzyme inhibitory peptides from soybean proteins. Food Chemistry 141, 2682–2690, 2013, doi:10.1016/j.foodchem.2013.04.064.
2013
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O InChI=1S/C19H28N4O5/c1-11(2)8-13(20)17(25)22-14(10-16(21)24)18(26)23-15(19(27)28)9-12-6-4-3-5-7-12/h3-7,11,13-15H,8-10,20H2,1-2H3,(H2,21,24)(H,22,25)(H,23,26)(H,27,28)/t13-,14-,15-/m0/s1 InChIKey=MDVZJYGNAGLPGJ-KKUMJFAQSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
511.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Gu Y., Wu J.
LC–MS/MS coupled with QSAR modeling in characterising of angiotensin I-converting enzyme inhibitory peptides from soybean proteins. Food Chemistry 141, 2682–2690, 2013, doi:10.1016/j.foodchem.2013.04.064.
2013
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O InChI=1S/C19H28N4O5/c1-11(2)8-13(20)17(25)22-14(10-16(21)24)18(26)23-15(19(27)28)9-12-6-4-3-5-7-12/h3-7,11,13-15H,8-10,20H2,1-2H3,(H2,21,24)(H,22,25)(H,23,26)(H,27,28)/t13-,14-,15-/m0/s1 InChIKey=MDVZJYGNAGLPGJ-KKUMJFAQSA-N
Additional Detail Fields 1 fields
3