TPDB

3D PDB MODEL

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TPDB ID TPDB48279

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antihypertensive Bitter Umami iDPPIV

Activity_category_statistics

Cardiometabolic peptides Food sensory peptides

Database_Source

AHTPDB Peptipedia Tastepeptides-Meta iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (Antihypertensive, Bitter, Umami, and other sources) peptide sequence curated from AHTPDB, Peptipedia, Tastepeptides-Meta, and other sources, with an available 3D structural model.

Sequence

AD

FASTA

>TPDB48279|Antihypertensive;Bitter;Umami;iDPPIV|length=2
AD

Formula C7H12N2O5

Absent Amino Acids RNCEQGHILKMFPSTWYV

Common Amino Acids AD

Mass 204.18

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -1

Boman Index 1.06

Hydrophobicity -0.850

Aliphatic Index 50.00

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

2

Formula

C7H12N2O5

Mass

204.18

PI

3.10

Net Charge

-1

Boman Index

1.06

Hydrophobicity

-0.850

Chemical_Mass

204.1801

Monoisotopic_Mass

204.0743

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 0.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.

Title Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)O InChI=1S/C7H12N2O5/c1-3(8)6(12)9-4(7(13)14)2-5(10)11/h3-4H,2,8H2,1H3,(H,9,12)(H,10,11)(H,13,14)/t3-,4-/m0/s1 InChIKey: XAEWTDMGFGHWFK-IMJSIDKUSA-N Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to AHTPDB database Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9695) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 145) Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 449)

Number_of_Residues

2