TPDB

3D PDB MODEL

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TPDB ID TPDB48274

Peptide_Name

ACE inhibitor from porcine hemoglobin

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

YTVF

FASTA

>TPDB48274|ACE inhibitors;Antihypertensive|length=4
YTVF

Formula C27H36N4O7

Absent Amino Acids ARNDCEQGHILKMPSW

Common Amino Acids FTYV

Mass 528.61

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -1.86

Hydrophobicity 1.250

Aliphatic Index 72.50

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 281.87

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

0

P

0

S

1

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 1

Length

4

Formula

C27H36N4O7

Mass

528.61

PI

5.94

Net Charge

-0

Boman Index

-1.86

Hydrophobicity

1.250

Chemical_Mass

528.5959

Monoisotopic_Mass

528.2575

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.23 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Ren Y., Wan D.-G., Lu X., Chen L., Zhang T., Guo J.-L.

Title

Isolation and characterization of angiotensin Iconverting enzyme inhibitor peptides derived from porcine hemoglobin. Scientific Research and Essays 6(30), 6262-6269, DOI: 10.5897/SRE11.326.

Year 2011

Literature Source Journal

Other

Number of Residues 4

Additional Info Activity expressed in (mg/ml).

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.23 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Ren Y., Wan D.-G., Lu X., Chen L., Zhang T., Guo J.-L.

Title

Isolation and characterization of angiotensin Iconverting enzyme inhibitor peptides derived from porcine hemoglobin. Scientific Research and Essays 6(30), 6262-6269, DOI: 10.5897/SRE11.326.

Year 2011

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 4

Additional Info Activity expressed in (mg/ml).

Number_of_Residues

4