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Peptide record

TPDB48249

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antihypertensive Bitter iDPPIV standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB48249
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antihypertensive Bitter iDPPIV
Cardiometabolic peptides Food sensory peptides
AHTPDB Peptipedia Tastepeptides-Meta iDPPIV
standard
No
A 3-aa standard natural multi-activity (Antihypertensive, Bitter, and iDPPIV) peptide sequence curated from AHTPDB, Peptipedia, Tastepeptides-Meta, and other sources, with an available 3D structural model.
Sequence
PPG
Physicochemical Analysis
C12H19N3O4
ARNDCEQHILKMFSTWYV
P
269.30
6.02
0
0
0
-0
0.91
-1.200
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C12H19N3O4
269.30
6.02
-0
0.91
-1.200
269.2962
269.1371
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
iDPPIV
2252.68 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lafarga T., O’Connor P., Hayes M.
Identification of novel dipeptidyl peptidase-IV andangiotensin-I-converting enzyme inhibitory peptides from meatproteins using in silico analysis. Peptides 59, 53-62
2014
Journal

Other

3
BIOPEP database of bioactive peptides SMILES: N1[C@H](C(=O)N2[C@H](C(=O)NCC(=O)O)CCC2)CCC1 InChI=1S/C12H19N3O4/c16-10(17)7-14-11(18)9-4-2-6-15(9)12(19)8-3-1-5-13-8/h8-9,13H,1-7H2,(H,14,18)(H,16,17)/t8-,9-/m0/s1 InChIKey: LEIKGVHQTKHOLM-IUCAKERBSA-N Bitter peptide according to BIOPEP database of sensory peptides and amino acids
Additional Detail Fields 1 fields
3