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Peptide record

TPDB48245

ACE inhibitor ACE inhibitors Antihypertensive Bitter standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB48245
ACE inhibitor
ACE inhibitors Antihypertensive Bitter
Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB Tastepeptides-Meta
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Bitter) peptide sequence curated from Peptipedia, AHTPDB, and Tastepeptides-Meta, with an available 3D structural model.
Sequence
PPP
Physicochemical Analysis
C15H23N3O4
ARNDCEQGHILKMFSTWYV
P
309.37
6.02
0
0
0
-0
1.35
-1.600
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C15H23N3O4
309.37
6.02
-0
1.35
-1.600
309.3599
309.1683
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
78.20 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu J., Aluko R. E.
Quantitative structure-activity relationship study of bitter di- and tri-peptides including relationship with angiotensin I-converting enzyme inhibitory activity. J. Peptide Sci., 13, 63-69, 2007
2007
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: C1C[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)O)NC1 InChI=1S/C15H23N3O4/c19-13(10-4-1-7-16-10)17-8-2-5-11(17)14(20)18-9-3-6-12(18)15(21)22/h10-12,16H,1-9H2,(H,21,22)/t10-,11-,12-/m0/s1 InChIKey: SBVPYBFMIGDIDX-SRVKXCTJSA-N Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the PubChem database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 6)
Evidence 2 Activity

Activity

IC50
Antihypertensive
78.20 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu J., Aluko R. E.
Quantitative structure-activity relationship study of bitter di- and tri-peptides including relationship with angiotensin I-converting enzyme inhibitory activity. J. Peptide Sci., 13, 63-69, 2007
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: C1C[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)O)NC1 InChI=1S/C15H23N3O4/c19-13(10-4-1-7-16-10)17-8-2-5-11(17)14(20)18-9-3-6-12(18)15(21)22/h10-12,16H,1-9H2,(H,21,22)/t10-,11-,12-/m0/s1 InChIKey: SBVPYBFMIGDIDX-SRVKXCTJSA-N Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the PubChem database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 6)
Additional Detail Fields 1 fields
3