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Peptide record

TPDB48241

LXY3 Antihypertensive Bitter Tumor-homing Peptides standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB48241
LXY3
Antihypertensive Bitter Tumor-homing Peptides
Cardiometabolic peptides Cancer-related peptides Food sensory peptides
AHTPDB Peptipedia Tastepeptides-Meta TumorHoPe2.0
standard
No
A 3-aa standard natural multi-activity (Antihypertensive, Bitter, and Tumor-homing Peptides) peptide sequence curated from AHTPDB, Peptipedia, Tastepeptides-Meta, and other sources, with an available 3D structural model.
C-terminal: hydroxyproline and norleucine/nitrile group
Sequence
GYG
Physicochemical Analysis
C13H17N3O5
ARNDCEQHILKMFPSTWV
G
295.30
5.94
0
0
1
-0
-0.92
-0.700
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
504.58
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
3
C13H17N3O5
295.30
5.94
-0
-0.92
-0.700
hydroxyproline and norleucine/nitrile group
cNGXGXXc
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Glioblastoma
α3β1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Discovery and characterization of a high-affinity and high-specificity peptide ligand LXY30 for in vivo targeting of α3 integrin-expressing human tumors
2016
Wenwu Xiao et al. EJNMMI Res. 2016 Dec 6. 18.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
human glioblastoma U-87MG cells
orthotopic U-87MG xenograft mouse models
Phage display library
Cyclic dipeptide, At 2nd position Tyrosine with a nitro group (-NO₂) attached at the 3-position of the aromatic ring.
Additional Detail Fields 2 fields
human glioblastoma U-87MG cells
orthotopic U-87MG xenograft mouse models