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Peptide record

TPDB48236

LXY4 Antihypertensive Bitter Tumor-homing Peptides standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB48236
LXY4
Antihypertensive Bitter Tumor-homing Peptides
Cardiometabolic peptides Cancer-related peptides Food sensory peptides
AHTPDB Peptipedia Tastepeptides-Meta TumorHoPe2.0
standard
No
A 3-aa standard natural multi-activity (Antihypertensive, Bitter, and Tumor-homing Peptides) peptide sequence curated from AHTPDB, Peptipedia, Tastepeptides-Meta, and other sources, with an available 3D structural model.
C-terminal: hydroxyproline and norleucine/nitrile group
Sequence
GFG
Physicochemical Analysis
C13H17N3O4
ARNDCEQHILKMPSTWYV
G
279.30
6.02
0
0
1
-0
-1.11
0.667
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C13H17N3O4
279.30
6.02
-0
-1.11
0.667
hydroxyproline and norleucine/nitrile group
cNGXGXXc
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Glioblastoma
α3β1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Discovery and characterization of a high-affinity and high-specificity peptide ligand LXY30 for in vivo targeting of α3 integrin-expressing human tumors
2016
Wenwu Xiao et al. EJNMMI Res. 2016 Dec 6. 18.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
human glioblastoma U-87MG cells
orthotopic U-87MG xenograft mouse models
Phage display library
Cyclic dipeptide, At 2nd position Phenylalanine (Phe) residue substituted with two fluorine atoms at the 3rd and 5th positions of the benzyl side chain's aromatic ring
Additional Detail Fields 2 fields
human glioblastoma U-87MG cells
orthotopic U-87MG xenograft mouse models