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Peptide record

TPDB48220

ACE inhibitor ACE inhibitors Antihypertensive iDPPIV standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB48220
ACE inhibitor
ACE inhibitors Antihypertensive iDPPIV
Cardiometabolic peptides
FermFooDB Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and iDPPIV) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
VRGP
Physicochemical Analysis
C18H33N7O5
ANDCEQHILKMFSTWY
RGPV
427.50
11.05
1
0
1
+1
1.34
-0.575
72.50
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
4
C18H33N7O5
427.50
11.05
+1
1.34
-0.575
427.4972
427.2536
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
120.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Gómez-Ruiz J.A., Taborda G., Amigo L., Recio I., Ramos M.
Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry. European Food Research and Technology, 2006, 223:595-601
2006
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C18H33N7O5/c1-10(2)14(19)16(28)24-11(5-3-7-22-18(20)21)15(27)23-9-13(26)25-8-4-6-12(25)17(29)30/h10-12,14H,3-9,19H2,1-2H3,(H,23,27)(H,24,28)(H,29,30)(H4,20,21,22)/t11-,12-,14-/m0/s1 InChIKey: SOQHEJRQFFCVQV-OBJOEFQTSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
120.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Gómez-Ruiz J.A., Taborda G., Amigo L., Recio I., Ramos M.
Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry. European Food Research and Technology, 2006, 223:595-601
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C18H33N7O5/c1-10(2)14(19)16(28)24-11(5-3-7-22-18(20)21)15(27)23-9-13(26)25-8-4-6-12(25)17(29)30/h10-12,14H,3-9,19H2,1-2H3,(H,23,27)(H,24,28)(H,29,30)(H4,20,21,22)/t11-,12-,14-/m0/s1 InChIKey: SOQHEJRQFFCVQV-OBJOEFQTSA-N
Additional Detail Fields 1 fields
4