TPDB

3D PDB MODEL

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TPDB ID TPDB48210

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antihypertensive Bitter iDPPIV

Activity_category_statistics

Cardiometabolic peptides Food sensory peptides

Database_Source

AHTPDB Peptipedia Tastepeptides-Meta iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (Antihypertensive, Bitter, and iDPPIV) peptide sequence curated from AHTPDB, Peptipedia, Tastepeptides-Meta, and other sources, with an available 3D structural model.

Sequence

SL

FASTA

>TPDB48210|Antihypertensive;Bitter;iDPPIV|length=2
SL

Formula C9H18N2O4

Absent Amino Acids ARNDCEQGHIKMFPTWYV

Common Amino Acids LS

Mass 218.25

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index -0.43

Hydrophobicity 1.500

Aliphatic Index 195.00

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

0

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

2

Formula

C9H18N2O4

Mass

218.25

PI

6.02

Net Charge

-0

Boman Index

-0.43

Hydrophobicity

1.500

Chemical_Mass

218.2495

Monoisotopic_Mass

218.1262

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 2517.08 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.

Title

Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides. Food Chemistry, 141, 644-653, 2013

Year 2013

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C9H18N2O4/c1-5(2)3-7(9(14)15)11-8(13)6(10)4-12/h5-7,12H,3-4,10H2,1-2H3,(H,11,13)(H,14,15)/t6-,7-/m0/s1 InChIKey=NFDYGNFETJVMSE-BQBZGAKWSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the EROP-Moscow database Peptide regulating phosphoglycerate kinase (EC 2.7.2.3) activity according to the BIOPEP-UWM database of bioactive peptides (ID 9955) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 492) Peptide regulating phosphoglycerate kinase (EC 2.7.2.3) activity according to the BIOPEP-UWM database of bioactive peptides

Number_of_Residues

2