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Peptide record

TPDB48201

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) VA Val-Ala Antihypertensive Bitter iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB48201
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) VA Val-Ala
Antihypertensive Bitter iDPPIV Selfassembly
Cardiometabolic peptides Food sensory peptides Self-assembling and biomaterial peptides
AHTPDB Peptipedia Tastepeptides-Meta iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (Antihypertensive, Bitter, iDPPIV, and other sources) peptide sequence curated from AHTPDB, Peptipedia, Tastepeptides-Meta, and other sources, with an available 3D structural model.
Sequence
VA
Physicochemical Analysis
C8H16N2O3
RNDCEQGHILKMFPSTWY
AV
188.23
6.02
0
0
2
-0
-0.10
3.000
195.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
2
C8H16N2O3
188.23
6.02
-0
-0.10
3.000
188.2236
188.1157
Self-Assembly Information 11 records
Record 1 Selfassembly

Source

26086903
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanowire Wire like structures
temperature: Room temperature solvent: 2- propanol concentration: 2mg/ml
Selfassembly; Nanostructure=Nanowire; Wire like structures; Trigger=temperature: Room temperature; solvent: 2- propanol; concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
Selfassembly
Record 2 Selfassembly

Source

26086903
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanorod Dense and well-structured rod-like structures
temperature: Room temperature solvent: 70% 2-propanol with pyridine concentration: 2mg/ml
Selfassembly; Nanostructure=Nanorod; Dense and well-structured rod-like structures; Trigger=temperature: Room temperature; solvent: 70% 2-propanol with pyridine; concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
Selfassembly
Record 3 Selfassembly

Source

26086903
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Square plate-like structures
temperature: Room temperature solvent: Pyrimidine concentration: 2mg/ml
Selfassembly; Nanostructure=Square plate-like structures; Trigger=temperature: Room temperature; solvent: Pyrimidine; concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
Selfassembly
Record 4 Selfassembly

Source

26086903
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Irregular rod like aggregate structure
temperature: Room temperature solvent: Ethanol concentration: 2mg/ml
Selfassembly; Nanostructure=Irregular rod like aggregate structure; Trigger=temperature: Room temperature; solvent: Ethanol; concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
Selfassembly
Record 5 Selfassembly

Source

26086903
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Irregular rod-like aggregates as well as plate-like structures
temperature: Room temperature solvent: Pyrimidine concentration: 0.5mg/ml
Selfassembly; Nanostructure=Irregular rod-like aggregates as well as plate-like structures; Trigger=temperature: Room temperature; solvent: Pyrimidine; concentration: 0.5mg/ml
Scanning Electron Microscopy (SEM)
Selfassembly
Record 6 Selfassembly

Source

26086903
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Rectangular plate-like
temperature: Room temperature solvent: Pyrimidine concentration: 1mg/ml
Selfassembly; Nanostructure=Rectangular plate-like; Trigger=temperature: Room temperature; solvent: Pyrimidine; concentration: 1mg/ml
Scanning Electron Microscopy (SEM)
Selfassembly
Record 7 Selfassembly

Source

26086903
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Irregular plates
temperature: Room temperature solvent: Pyrimidine concentration: 4mg/ml
Selfassembly; Nanostructure=Irregular plates; Trigger=temperature: Room temperature; solvent: Pyrimidine; concentration: 4mg/ml
Scanning Electron Microscopy (SEM)
Selfassembly
Record 8 Selfassembly

Source

26086903
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Irregular rod-like structures
temperature: Room temperature solvent: 2- propanol concentration: 0.5, 1.0, 4.0mg/ml
Selfassembly; Nanostructure=Irregular rod-like structures; Trigger=temperature: Room temperature; solvent: 2- propanol; concentration: 0.5, 1.0, 4.0mg/ml
Scanning Electron Microscopy (SEM)
Selfassembly
Record 9 Selfassembly

Source

26086903
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Rectangular-plate
temperature: Room temperature solvent: 30% 2-propanol with pyridine concentration: 2mg/ml
Selfassembly; Nanostructure=Rectangular-plate; Trigger=temperature: Room temperature; solvent: 30% 2-propanol with pyridine; concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
Selfassembly
Record 10 Selfassembly

Source

26086903
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Extended rectangular-plate
temperature: Room temperature solvent: 50% 2-propanol with pyridine concentration: 2mg/ml
Selfassembly; Nanostructure=Extended rectangular-plate; Trigger=temperature: Room temperature; solvent: 50% 2-propanol with pyridine; concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
Selfassembly
Record 11 Selfassembly

Source

27841381
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
Selfassembly; Nanostructure=Nanoparticles
TEM and SEM
Selfassembly
Evidence Records 12 records
Evidence 1 Activity

Activity

IC50
iDPPIV
168.24 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides. Food Chemistry, 141, 644–653
2013
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)O InChI=1S/C8H16N2O3/c1-4(2)6(9)7(11)10-5(3)8(12)13/h4-6H,9H2,1-3H3,(H,10,11)(H,12,13)/t5-,6-/m0/s1 InChIKey: HSRXSKHRSXRCFC-WDSKDSINSA-N The first reference concerning peptide: Bella A. M., Erickson R. H. Jr., Kim Y. S. Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV: kinetic properties and substrate specifcities of the purified enzyme. Arch. Biochem. Biophys. 218 (1), 156-162 (1982) Inhibitor of Tripeptidyl peptidase 2 (TPP 2) (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BRENDA database, the ChEMBL database Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids, the ChEMBL database
Evidence 2 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanowire Wire like structures Trigger=temperature: Room temperature solvent: 2- propanol concentration: 2mg/ml
Nanowire Wire like structures

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: 2- propanol concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanorod Dense and well-structured rod-like structures Trigger=temperature: Room temperature solvent: 70% 2-propanol with pyridine concentration: 2mg/ml
Nanorod Dense and well-structured rod-like structures

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: 70% 2-propanol with pyridine concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Square plate-like structures Trigger=temperature: Room temperature solvent: Pyrimidine concentration: 2mg/ml
Square plate-like structures

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Pyrimidine concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1418 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 5 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Irregular rod like aggregate structure Trigger=temperature: Room temperature solvent: Ethanol concentration: 2mg/ml
Irregular rod like aggregate structure

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Ethanol concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1420 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 6 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Irregular rod-like aggregates as well as plate-like structures Trigger=temperature: Room temperature solvent: Pyrimidine concentration: 0.5mg/ml
Irregular rod-like aggregates as well as plate-like structures

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Pyrimidine concentration: 0.5mg/ml
Scanning Electron Microscopy (SEM)
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1421 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 7 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Rectangular plate-like Trigger=temperature: Room temperature solvent: Pyrimidine concentration: 1mg/ml
Rectangular plate-like

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Pyrimidine concentration: 1mg/ml
Scanning Electron Microscopy (SEM)
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1422 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 8 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Irregular plates Trigger=temperature: Room temperature solvent: Pyrimidine concentration: 4mg/ml
Irregular plates

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Pyrimidine concentration: 4mg/ml
Scanning Electron Microscopy (SEM)
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1423 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 9 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Irregular rod-like structures Trigger=temperature: Room temperature solvent: 2- propanol concentration: 0.5, 1.0, 4.0mg/ml
Irregular rod-like structures

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: 2- propanol concentration: 0.5, 1.0, 4.0mg/ml
Scanning Electron Microscopy (SEM)
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1424 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 10 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Rectangular-plate Trigger=temperature: Room temperature solvent: 30% 2-propanol with pyridine concentration: 2mg/ml
Rectangular-plate

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: 30% 2-propanol with pyridine concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1427 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 11 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Extended rectangular-plate Trigger=temperature: Room temperature solvent: 50% 2-propanol with pyridine concentration: 2mg/ml
Extended rectangular-plate

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: 50% 2-propanol with pyridine concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1428 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 12 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
TEM and SEM
27841381
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1893 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Additional Detail Fields 6 fields
temperature: Room temperature solvent: 2- propanol concentration: 2mg/ml solvent: 70% 2-propanol with pyridine solvent: Pyrimidine solvent: Ethanol concentration: 0.5mg/ml concentration: 1mg/ml concentration: 4mg/ml concentration: 0.5, 1.0, 4.0mg/ml solvent: 30% 2-propanol with pyridine solvent: 50% 2-propanol with pyridine
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database. SAPdb ID 1418 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row. SAPdb ID 1420 SAPdb ID 1421 SAPdb ID 1422 SAPdb ID 1423 SAPdb ID 1424 SAPdb ID 1427 SAPdb ID 1428 SAPdb ID 1893
2
26086903 27841381
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly