TPDB

3D PDB MODEL

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TPDB ID TPDB48198

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Renin inhibitor

Activity

Antihypertensive iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

AHTPDB Peptipedia iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (Antihypertensive and iDPPIV) peptide sequence curated from AHTPDB, Peptipedia, and iDPPIV, with an available 3D structural model.

Sequence

QF

FASTA

>TPDB48198|Antihypertensive;iDPPIV|length=2
QF

Formula C14H19N3O4

Absent Amino Acids ARNDCEGHILKMPSTWYV

Common Amino Acids QF

Mass 293.32

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index -0.55

Hydrophobicity -0.350

Aliphatic Index 0.00

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

2

Formula

C14H19N3O4

Mass

293.32

PI

6.02

Net Charge

-0

Boman Index

-0.55

Hydrophobicity

-0.350

Chemical_Mass

293.3176

Monoisotopic_Mass

293.1371

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007)

Detail Activity renin inhibitor

Activity Code ren

Source & Reference

Database Source AHTPDB

Authors Udenigwe C. Li H. Aluko R.

Title Quantitative structure-activity relationship modeling of renin-inhibiting dipeptides. Amino Acids, 42, 1379–1386, 2012

Year 2012

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C14H19N3O4/c15-10(6-7-12(16)18)13(19)17-11(14(20)21)8-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H2,16,18)(H,17,19)(H,20,21)/t10-,11-/m0/s1 InChIKey: VHLZDSUANXBJHW-QWRGUYRKSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 9431) Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 0.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.

Title Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C14H19N3O4/c15-10(6-7-12(16)18)13(19)17-11(14(20)21)8-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H2,16,18)(H,17,19)(H,20,21)/t10-,11-/m0/s1 InChIKey: VHLZDSUANXBJHW-QWRGUYRKSA-N Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 9431) Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database

Number_of_Residues

2