TPDB

3D PDB MODEL

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TPDB ID TPDB48195

Peptide_Name

ACE inhibitor

Activity

Antihypertensive Bitter

Activity_category_statistics

Cardiometabolic peptides Food sensory peptides

Database_Source

AHTPDB Peptipedia Tastepeptides-Meta

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (Antihypertensive and Bitter) peptide sequence curated from AHTPDB, Peptipedia, and Tastepeptides-Meta, with an available 3D structural model.

Sequence

PPF

FASTA

>TPDB48195|Antihypertensive;Bitter|length=3
PPF

Formula C19H25N3O4

Absent Amino Acids ARNDCEQGHILKMSTWYV

Common Amino Acids P

Mass 359.43

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index -0.23

Hydrophobicity -0.133

Aliphatic Index 0.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

2

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

3

Formula

C19H25N3O4

Mass

359.43

PI

6.02

Net Charge

-0

Boman Index

-0.23

Hydrophobicity

-0.133

Chemical_Mass

359.4185

Monoisotopic_Mass

359.1839

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 239.33 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Gu J., Yue S., Yang X., Lu Z., Wang Z., Wei X., Zhou L., Zhao Z., Shi Z., Zhao Z.

Title

Unlocking novel angiotensin-converting enzyme inhibitory peptides from Nili Ravi buffalo milk β-casein: A synergistic strategy combining targeted hydrolysis, 3D-QSAR modeling, and mechanistic insights. Food Biosci., 71, 107346, 2025

Year 2025

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides BIOPEP-UWM database of sensory peptides and amino acids SMILES: N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C19H25N3O4/c23-17(21-15(19(25)26)12-13-6-2-1-3-7-13)16-9-5-11-22(16)18(24)14-8-4-10-20-14/h1-3,6-7,14-16,20H,4-5,8-12H2,(H,21,23)(H,25,26)/t14-,15-,16-/m0/s1 InChIKey=NAIPAPCKKRCMBL-JYJNAYRXSA-N Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 59)

Number_of_Residues

3