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Peptide record

TPDB48194

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) diprotin A Antihypertensive iDPPIV standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB48194
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) diprotin A
Antihypertensive iDPPIV
Cardiometabolic peptides
AHTPDB Peptipedia iDPPIV
standard
No
A 3-aa standard natural multi-activity (Antihypertensive and iDPPIV) peptide sequence curated from AHTPDB, Peptipedia, and iDPPIV, with an available 3D structural model.
Sequence
IPI
Physicochemical Analysis
C17H31N3O4
ARNDCEQGHLKMFSTWYV
I
341.45
6.02
0
0
2
-0
-0.17
2.467
260.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C17H31N3O4
341.45
6.02
-0
-0.17
2.467
341.4445
341.2307
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
iDPPIV
7.40 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Maruyama S., Ohmori T., Nakagami T.
Prolylendopeptidase inhibitory activity of a glial fibrillary acidic protein fragment and other proline-rich peptides. Biosci. Biotech. Biochem., 60, 358-359 (1996)
1996
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)O)[C@H](CC)C)CCC1)[C@H](CC)C InChI=1S/C17H31N3O4/c1-5-10(3)13(18)16(22)20-9-7-8-12(20)15(21)19-14(17(23)24)11(4)6-2/h10-14H,5-9,18H2,1-4H3,(H,19,21)(H,23,24)/t10-,11-,12-,13-,14-/m0/s1 InChIKey=JNTMAZFVYNDPLB-PEDHHIEDSA-N Information concerning Dipeptidyl Peptidase IV (synonym: Dipeptidyl Aminopeptidase IV) (EC 3.4.14.5) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: S09.003 Another measured value of IC50 (EC50) of peptide is 3.50 um (Leiting B., Pryor K. D., Wu J. K., Marsilio F., Patel R. A., Craik C. S., Ellman J. A., Cummings R. T., Thornberry N. A., 2003, Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. Biochem. J., 371, 525-532) and 4.23 um (Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J., 2013, Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides. Food Chemistry, 141, 644-653). Another references concerning peptide: Lacroix I. M. E., Li-Chan E. C. Y., 2012, Evaluation of the potential of dietary proteins as precursors of dipeptidyl peptidase (DPP)-IV inhibitors by an in silico approach. J. Funct. Foods, 4, 403-422 Nongonierma A. B., FitzGerald R. J., 2013, Inhibition of dipeptidyl peptidase IV (DPP-IV) by proline containing casein-derived peptides. J. Funct. Foods, 5, 1909-1917 Davy A., Thomsen K. K., Juliano M. A., Alves L. C., Svendsen I., Simpson D. J., Purification and characterization of barley dipeptidyl peptidase IV. Plant Physiology, 122, 425-431 (2000). Inhibitor of tripeptidyl aminopeptidase (MEROPS ID: S08.A56) according to the ChEMBL database Inhibitor of Tripeptidyl peptidase 2 (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BRENDA database Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database
Additional Detail Fields 1 fields
3