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Peptide record

TPDB48162

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antihypertensive iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB48162
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antihypertensive iDPPIV
Cardiometabolic peptides
AHTPDB Peptipedia iDPPIV
standard
No
A 2-aa standard natural multi-activity (Antihypertensive and iDPPIV) peptide sequence curated from AHTPDB, Peptipedia, and iDPPIV, with an available 3D structural model.
Sequence
WQ
Physicochemical Analysis
C16H20N4O4
ARNDCEGHILKMFPSTYV
QW
332.36
6.02
0
0
1
-0
-1.27
-2.200
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1654.84
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
2
C16H20N4O4
332.36
6.02
-0
-1.27
-2.200
332.3536
332.1480
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
iDPPIV
120.30 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
In silico approaches to predict the potential of milk protein-derived peptides as dipeptidyl peptidase IV (DPP-IV) inhibitors. Peptides 57, 43-51, 2014
2014
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C16H20N4O4/c17-11(7-9-8-19-12-4-2-1-3-10(9)12)15(22)20-13(16(23)24)5-6-14(18)21/h1-4,8,11,13,19H,5-7,17H2,(H2,18,21)(H,20,22)(H,23,24)/t11-,13-/m0/s1 InChIKey=NZCPCJCJZHKFGZ-AAEUAGOBSA-N Antagonist of Peroxisome proliferator-activated receptor γ (PPARγ) according to the BIOPEP-UWM database of bioactive peptides the ChEMBL database
Additional Detail Fields 1 fields
2