TPDB

3D PDB MODEL

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TPDB ID TPDB48159

Peptide_Name

beta-lactokinin

Activity

ACE inhibitors Antihypertensive Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Neuroactive peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

HIRL

FASTA

>TPDB48159|ACE inhibitors;Antihypertensive;Neuropeptide|length=4
HIRL

Formula C24H43N9O5

Absent Amino Acids ANDCEQGKMFPSTWYV

Common Amino Acids RHIL

Mass 537.66

PI 11.05

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 0.90

Hydrophobicity 0.150

Aliphatic Index 195.00

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

1

I

1

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

4

Formula

C24H43N9O5

Mass

537.66

PI

11.05

Net Charge

+1

Boman Index

0.90

Hydrophobicity

0.150

Chemical_Mass

537.6538

Monoisotopic_Mass

537.3378

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 1153.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Mullally M. M., Meisel H., FitzGerald R. J.

Title

Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261, 1996

Year 1996

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC1=CN=CN1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C24H43N9O5/c1-5-14(4)19(33-20(34)16(25)10-15-11-28-12-30-15)22(36)31-17(7-6-8-29-24(26)27)21(35)32-18(23(37)38)9-13(2)3/h11-14,16-19H,5-10,25H2,1-4H3,(H,28,30)(H,31,36)(H,32,35)(H,33,34)(H,37,38)(H4,26,27,29)/t14-,16-,17-,18-,19-/m0/s1 InChIKey=HXOFYGXGSKBHGL-GBBGEASQSA-N Neuropeptide according to the BIOPEP-UWM database of bioactive peptides (ID 10022) the MBPDB database

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 1153.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Mullally M. M., Meisel H., FitzGerald R. J.

Title

Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261, 1996

Year 1996

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC1=CN=CN1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C24H43N9O5/c1-5-14(4)19(33-20(34)16(25)10-15-11-28-12-30-15)22(36)31-17(7-6-8-29-24(26)27)21(35)32-18(23(37)38)9-13(2)3/h11-14,16-19H,5-10,25H2,1-4H3,(H,28,30)(H,31,36)(H,32,35)(H,33,34)(H,37,38)(H4,26,27,29)/t14-,16-,17-,18-,19-/m0/s1 InChIKey=HXOFYGXGSKBHGL-GBBGEASQSA-N Neuropeptide according to the BIOPEP-UWM database of bioactive peptides (ID 10022) the MBPDB database

Number_of_Residues

4