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Peptide record

TPDB48154

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antihypertensive iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB48154
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antihypertensive iDPPIV
Cardiometabolic peptides
AHTPDB AHTpin Peptipedia iDPPIV
standard
No
A 2-aa standard natural multi-activity (Antihypertensive and iDPPIV) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.
Sequence
MA
Physicochemical Analysis
C8H16N2O3S1
RNDCEQGHILKFPSTWYV
AM
220.29
6.02
0
0
2
-0
-0.40
1.850
50.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
1
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C8H16N2O3S1
220.29
6.02
-0
-0.40
1.850
220.2897
220.0878
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Bella A. M., Erickson R. H. Jr., Kim Y. S.
Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV: kinetic properties and substrate specifities of the purified enzyme. Arch. Biochem. Biophys. 218 (1), 156-162 (1982))
1982
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)O InChI=1S/C8H16N2O3S/c1-5(8(12)13)10-7(11)6(9)3-4-14-2/h5-6H,3-4,9H2,1-2H3,(H,10,11)(H,12,13)/t5-,6-/m0/s1 InChIKey=JHKXZYLNVJRAAJ-WDSKDSINSA-N Inhibitor of citrulline uptake in yeasts according to the ChEMBL database Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the EROP-Moscow database
Additional Detail Fields 1 fields
2