TPDB

3D PDB MODEL

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TPDB ID TPDB48153

Peptide_Name

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antihypertensive iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

AHTPDB AHTpin Peptipedia iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (Antihypertensive and iDPPIV) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.

Sequence

YS

FASTA

>TPDB48153|Antihypertensive;iDPPIV|length=2
YS

Formula C12H16N2O5

Absent Amino Acids ARNDCEQGHILKMFPTWV

Common Amino Acids SY

Mass 268.27

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index -0.81

Hydrophobicity -1.050

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 555.41

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

1

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0

Length

2

Formula

C12H16N2O5

Mass

268.27

PI

5.94

Net Charge

-0

Boman Index

-0.81

Hydrophobicity

-1.050

Chemical_Mass

268.2652

Monoisotopic_Mass

268.1055

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 412.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Norris R., Casey F., FitzGerald R. J., Shields D., Mooney C.

Title Predictive modelling of angiotensin converting enzyme inhibitory dipeptides. Food Chem., 133, 1349-1354, 2012

Year 2012

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CO)C(=O)O InChI=1S/C12H16N2O5/c13-9(5-7-1-3-8(16)4-2-7)11(17)14-10(6-15)12(18)19/h1-4,9-10,15-16H,5-6,13H2,(H,14,17)(H,18,19)/t9-,10-/m0/s1 InChIKey=ZSXJENBJGRHKIG-UWVGGRQHSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8945)

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 0.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.

Title Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CO)C(=O)O InChI=1S/C12H16N2O5/c13-9(5-7-1-3-8(16)4-2-7)11(17)14-10(6-15)12(18)19/h1-4,9-10,15-16H,5-6,13H2,(H,14,17)(H,18,19)/t9-,10-/m0/s1 InChIKey=ZSXJENBJGRHKIG-UWVGGRQHSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the EROP-Moscow database

Number_of_Residues

2