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Peptide record

TPDB48142

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) L-Lysine(Lys)-L-glutamic acid(Glu) dipeptide ACE inhibitors Antihypertensive iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB48142
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) L-Lysine(Lys)-L-glutamic acid(Glu) dipeptide
ACE inhibitors Antihypertensive iDPPIV Selfassembly
Cardiometabolic peptides Self-assembling and biomaterial peptides
Peptipedia AHTPDB iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, iDPPIV, and other sources) peptide sequence curated from Peptipedia, AHTPDB, iDPPIV, and other sources, with an available 3D structural model.
Sequence
KE
Physicochemical Analysis
C11H21N3O5
ARNDCQGHILMFPSTWYV
EK
275.30
6.94
1
1
0
-0
3.01
-3.700
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C11H21N3O5
275.30
6.94
-0
3.01
-3.700
275.3007
275.1476
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

27940033
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanofiber Fibrils
pH: 7.4 temperature: Room temperature solvent: DMSO/H2O
Selfassembly; Nanostructure=Nanofiber; Fibrils; Trigger=pH: 7.4; temperature: Room temperature; solvent: DMSO/H2O
FT-IR, SEM and XRD (X-ray diffraction)
Selfassembly
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

2
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73
2015
Journal

Other

2
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber Fibrils Trigger=pH: 7.4 temperature: Room temperature solvent: DMSO/H2O
Nanofiber Fibrils

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 7.4 temperature: Room temperature solvent: DMSO/H2O
FT-IR, SEM and XRD (X-ray diffraction)
27940033
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
pH: 7.4 temperature: Room temperature solvent: DMSO/H2O
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
27940033
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly