Back to search

Peptide record

TPDB48141

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Umami iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB48141
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Umami iDPPIV
Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Umami, and other sources) peptide sequence curated from Peptipedia, AHTPDB, Tastepeptides-Meta, and other sources, with an available 3D structural model.
Sequence
EK
Physicochemical Analysis
C11H21N3O5
ARNDCQGHILMFPSTWYV
EK
275.30
6.94
1
1
0
-0
3.01
-3.700
0.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C11H21N3O5
275.30
6.94
-0
3.01
-3.700
275.3007
275.1476
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1 MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: C(CCN)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)N InChI=1S/C11H21N3O5/c12-6-2-1-3-8(11(18)19)14-10(17)7(13)4-5-9(15)16/h7-8H,1-6,12-13H2,(H,14,17)(H,15,16)(H,18,19)/t7-,8-/m0/s1 InChIKey=BBBXWRGITSUJPB-YUMQZZPRSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5 MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8558), the EROP-Moscow database Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 364)
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1 MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: C(CCN)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)N InChI=1S/C11H21N3O5/c12-6-2-1-3-8(11(18)19)14-10(17)7(13)4-5-9(15)16/h7-8H,1-6,12-13H2,(H,14,17)(H,15,16)(H,18,19)/t7-,8-/m0/s1 InChIKey=BBBXWRGITSUJPB-YUMQZZPRSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5 MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8558), the EROP-Moscow database Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 364)
Evidence 3 Activity

Activity

IC50
iDPPIV
3216.75 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides. Food Chemistry, 141, 644-653.
2013
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: C(CCN)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)N InChI=1S/C11H21N3O5/c12-6-2-1-3-8(11(18)19)14-10(17)7(13)4-5-9(15)16/h7-8H,1-6,12-13H2,(H,14,17)(H,15,16)(H,18,19)/t7-,8-/m0/s1 InChIKey=BBBXWRGITSUJPB-YUMQZZPRSA-N Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1 MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 8558) Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 364)
Additional Detail Fields 1 fields
2