Back to search

Peptide record

TPDB48134

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Umami iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB48134
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Umami iDPPIV
Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Umami, and other sources) peptide sequence curated from Peptipedia, AHTPDB, Tastepeptides-Meta, and other sources, with an available 3D structural model.
Sequence
TE
Physicochemical Analysis
C9H16N2O6
ARNDCQGHILKMFPSWYV
ET
248.24
3.29
0
1
0
-1
2.16
-2.100
0.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C9H16N2O6
248.24
3.29
-1
2.16
-2.100
248.2325
248.1004
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

2
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)CCC(=O)O)[C@H](O)C InChI=1S/C9H16N2O6/c1-4(12)7(10)8(15)11-5(9(16)17)2-3-6(13)14/h4-5,7,12H,2-3,10H2,1H3,(H,11,15)(H,13,14)(H,16,17)/t4-,5+,7+/m1/s1 InChIKey: BECPPKYKPSRKCP-ZDLURKLDSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8899) Umami peptide according to the BIOPEP database of sensory peptides and amino acids the EROP-Moscow database
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)CCC(=O)O)[C@H](O)C InChI=1S/C9H16N2O6/c1-4(12)7(10)8(15)11-5(9(16)17)2-3-6(13)14/h4-5,7,12H,2-3,10H2,1H3,(H,11,15)(H,13,14)(H,16,17)/t4-,5+,7+/m1/s1 InChIKey: BECPPKYKPSRKCP-ZDLURKLDSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8899) Umami peptide according to the BIOPEP database of sensory peptides and amino acids the EROP-Moscow database
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73
2015
Journal

Other

2
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)CCC(=O)O)[C@H](O)C InChI=1S/C9H16N2O6/c1-4(12)7(10)8(15)11-5(9(16)17)2-3-6(13)14/h4-5,7,12H,2-3,10H2,1H3,(H,11,15)(H,13,14)(H,16,17)/t4-,5+,7+/m1/s1 InChIKey: BECPPKYKPSRKCP-ZDLURKLDSA-N Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001) according to the AHTPDB database the BIOPEP database of bioactive peptides (ID 7830) Umami peptide according to the BIOPEP database of sensory peptides and amino acids the EROP-Moscow database
Additional Detail Fields 1 fields
2