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Peptide record

TPDB48133

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Bitter Umami iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB48133
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Bitter Umami iDPPIV
Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, Tastepeptides-Meta, and other sources, with an available 3D structural model.
Sequence
EV
Physicochemical Analysis
C10H18N2O5
ARNDCQGHILKMFPSTWY
EV
246.26
3.29
0
1
1
-1
2.09
0.350
145.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
2
C10H18N2O5
246.26
3.29
-1
2.09
0.350
246.2596
246.1211
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

2
BIOPEP database of bioactive peptides SMILES: CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)N InChI=1S/C10H18N2O5/c1-5(2)8(10(16)17)12-9(15)6(11)3-4-7(13)14/h5-6,8H,3-4,11H2,1-2H3,(H,12,15)(H,13,14)(H,16,17)/t6-,8-/m0/s1 InChIKey: SITLTJHOQZFJGG-XPUUQOCRSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide found in chicken meat protein hydrolysate: Maehashi K., Matsuzaki M., Yamamoto Y., Udaka, S. 1999, Isolation of peptides from an enzymatic hydrolysate of food proteins and characterization of their taste properties. Biosci. Biotech. Biochem., 63, 555-559 Sour peptide according to the BIOPEP database of sensory peptides and amino acids (ID 267) Sweet peptide according to the BIOPEP database of sensory peptides and amino acids (ID 308) Umami peptide according to the BIOPEP database of sensory peptides and amino acids (ID 309) Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 357)
Evidence 2 Activity

Activity

EC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP database of bioactive peptides SMILES: CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)N InChI=1S/C10H18N2O5/c1-5(2)8(10(16)17)12-9(15)6(11)3-4-7(13)14/h5-6,8H,3-4,11H2,1-2H3,(H,12,15)(H,13,14)(H,16,17)/t6-,8-/m0/s1 InChIKey: SITLTJHOQZFJGG-XPUUQOCRSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide found in chicken meat protein hydrolysate: Maehashi K., Matsuzaki M., Yamamoto Y., Udaka, S. 1999, Isolation of peptides from an enzymatic hydrolysate of food proteins and characterization of their taste properties. Biosci. Biotech. Biochem., 63, 555-559 Sour peptide according to the BIOPEP database of sensory peptides and amino acids (ID 267) Sweet peptide according to the BIOPEP database of sensory peptides and amino acids (ID 308) Umami peptide according to the BIOPEP database of sensory peptides and amino acids (ID 309) Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 357)
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73
2015
Journal

Other

2
Additional Detail Fields 1 fields
2