Back to search

Peptide record

TPDB48123

ACE inhibitor from alphas1-CN (136-139) ACE inhibitors Antihypertensive standard
4 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB48123
ACE inhibitor from alphas1-CN (136-139)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LFRQ
Physicochemical Analysis
C26H42N8O6
ANDCEGHIKMPSTWYV
RQLF
562.67
11.05
1
0
2
+1
-0.30
-0.350
97.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C26H42N8O6
562.67
11.05
+1
-0.30
-0.350
562.6600
562.3218
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
17.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315, 2006
2006
book

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O InChI=1S/C26H42N8O6/c1-15(2)13-17(27)22(36)34-20(14-16-7-4-3-5-8-16)24(38)32-18(9-6-12-31-26(29)30)23(37)33-19(25(39)40)10-11-21(28)35/h3-5,7-8,15,17-20H,6,9-14,27H2,1-2H3,(H2,28,35)(H,32,38)(H,33,37)(H,34,36)(H,39,40)(H4,29,30,31)/t17-,18-,19-,20-/m0/s1 InChIKey=MEFWELQAHGVFCB-MUGJNUQGSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
17.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315, 2006
2006
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O InChI=1S/C26H42N8O6/c1-15(2)13-17(27)22(36)34-20(14-16-7-4-3-5-8-16)24(38)32-18(9-6-12-31-26(29)30)23(37)33-19(25(39)40)10-11-21(28)35/h3-5,7-8,15,17-20H,6,9-14,27H2,1-2H3,(H2,28,35)(H,32,38)(H,33,37)(H,34,36)(H,39,40)(H4,29,30,31)/t17-,18-,19-,20-/m0/s1 InChIKey=MEFWELQAHGVFCB-MUGJNUQGSA-N
Additional Detail Fields 1 fields
4