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Peptide record

TPDB48115

ACE inhibitor ACE inhibitors Antihypertensive Bitter Umami standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB48115
ACE inhibitor
ACE inhibitors Antihypertensive Bitter Umami
Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
EA
Physicochemical Analysis
C8H14N2O5
RNDCQGHILKMFPSTWYV
AE
218.21
3.29
0
1
1
-1
1.85
-0.850
50.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C8H14N2O5
218.21
3.29
-1
1.85
-0.850
218.2066
218.0899
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
10000.00 µM
Inhibitor of angiotensin I-converting enzyme (EC 3.4.15.1 MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Inhibitor of angiotensin I-converting enzyme (EC 3.4.15.1 MEROPS ID: M02-001)
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C8H14N2O5/c1-4(8(14)15)10-7(13)5(9)2-3-6(11)12/h4-5H,2-3,9H2,1H3,(H,10,13)(H,11,12)(H,14,15)/t4-,5-/m0/s1 InChIKey: JZDHUJAFXGNDSB-WHFBIAKZSA-N Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9650) Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 362) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 363)
Evidence 2 Activity

Activity

IC50
Antihypertensive
10000.00 µM
Inhibitor of angiotensin I-converting enzyme (EC 3.4.15.1 MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Inhibitor of angiotensin I-converting enzyme (EC 3.4.15.1 MEROPS ID: M02-001)
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C8H14N2O5/c1-4(8(14)15)10-7(13)5(9)2-3-6(11)12/h4-5H,2-3,9H2,1H3,(H,10,13)(H,11,12)(H,14,15)/t4-,5-/m0/s1 InChIKey: JZDHUJAFXGNDSB-WHFBIAKZSA-N Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9650) Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 362) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 363)
Additional Detail Fields 1 fields
2