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Peptide record

TPDB48114

ACE inhibitor ACE inhibitors Antidiabetic Antihypertensive Bitter Neuropeptide Umami standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB48114
ACE inhibitor
ACE inhibitors Antidiabetic Antihypertensive Bitter Neuropeptide Umami
Cardiometabolic peptides Neuroactive peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antidiabetic, Antihypertensive, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
DA
Physicochemical Analysis
C7H12N2O5
RNCEQGHILKMFPSTWYV
AD
204.18
3.10
0
1
1
-1
1.06
-0.850
50.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C7H12N2O5
204.18
3.10
-1
1.06
-0.850
204.1801
204.0743
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
3800.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cushman D. W.
Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.
1981
book

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)O InChI=1S/C7H12N2O5/c1-3(7(13)14)9-6(12)4(8)2-5(10)11/h3-4H,2,8H2,1H3,(H,9,12)(H,10,11)(H,13,14)/t3-,4-/m0/s1 InChIKey: DVUFTQLHHHJEMK-IMJSIDKUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl-peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9492), the BRENDA database Inhibitor of Glutamate carboxypeptidase II (EC 3.4.17.21) (MEROPS ID: M28.010) according to the BRENDA database Activator of Carbonic anhydrase (EC 4.2.1.1) according to the ChEMBL database the PubChem database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 230) Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 350)
Evidence 2 Activity

Activity

IC50
Antihypertensive
3800.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cushman D. W.
Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.
1981
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)O InChI=1S/C7H12N2O5/c1-3(7(13)14)9-6(12)4(8)2-5(10)11/h3-4H,2,8H2,1H3,(H,9,12)(H,10,11)(H,13,14)/t3-,4-/m0/s1 InChIKey: DVUFTQLHHHJEMK-IMJSIDKUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl-peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9492), the BRENDA database Inhibitor of Glutamate carboxypeptidase II (EC 3.4.17.21) (MEROPS ID: M28.010) according to the BRENDA database Activator of Carbonic anhydrase (EC 4.2.1.1) according to the ChEMBL database the PubChem database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 230) Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 350)
Additional Detail Fields 1 fields
2