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Peptide record

TPDB48113

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB48113
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive iDPPIV
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and iDPPIV) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
RA
Physicochemical Analysis
C9H19N5O3
NDCEQGHILKMFPSTWYV
AR
245.28
11.05
1
0
1
+1
0.64
-1.350
50.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C9H19N5O3
245.28
11.05
+1
0.64
-1.350
245.2781
245.1484
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
460.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Cushman D. W.
Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.
1981
book

Other

2
BIOPEP database of bioactive peptides SMILES: N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)O InChI=1S/C9H19N5O3/c1-5(8(16)17)14-7(15)6(10)3-2-4-13-9(11)12/h5-6H,2-4,10H2,1H3,(H,14,15)(H,16,17)(H4,11,12,13)/t5-,6-/m0/s1 InChIKey: WVRUNFYJIHNFKD-WDSKDSINSA-N Peptide activating ubiquitin-mediated proteolysis according to the BIOPEP database of bioactive peptides (ID 4005), the EROP-Moscow database Peptide inhibiting UBR protein according to the ChEMBL database the PubChem database Inhibitor of Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8526) Inhibitor of Bleomycin hydrolase (EC 3.4.22.40) (MEROPS ID: C01.084) according to the BRENDA database Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 420)
Evidence 2 Activity

Activity

IC50
Antihypertensive
460.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cushman D. W.
Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.
1981
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP database of bioactive peptides SMILES: N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)O InChI=1S/C9H19N5O3/c1-5(8(16)17)14-7(15)6(10)3-2-4-13-9(11)12/h5-6H,2-4,10H2,1H3,(H,14,15)(H,16,17)(H4,11,12,13)/t5-,6-/m0/s1 InChIKey: WVRUNFYJIHNFKD-WDSKDSINSA-N Peptide activating ubiquitin-mediated proteolysis according to the BIOPEP database of bioactive peptides (ID 4005), the EROP-Moscow database Peptide inhibiting UBR protein according to the ChEMBL database the PubChem database Inhibitor of Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8526) Inhibitor of Bleomycin hydrolase (EC 3.4.22.40) (MEROPS ID: C01.084) according to the BRENDA database Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 420)
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Hikida A., Ito K., Motoyama T., Kato R., Kawarasaki Y.
Systematic analysis of a dipeptide library for inhibitor development using human dipeptidyl peptidase IV produced by a Saccharomyces cerevisiae expression system. Biochemical and Biophysical Research Communications 430, 1217-1222.
2013
Journal

Other

2
BIOPEP database of bioactive peptides SMILES: N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)O InChI=1S/C9H19N5O3/c1-5(8(16)17)14-7(15)6(10)3-2-4-13-9(11)12/h5-6H,2-4,10H2,1H3,(H,14,15)(H,16,17)(H4,11,12,13)/t5-,6-/m0/s1 InChIKey: WVRUNFYJIHNFKD-WDSKDSINSA-N Peptide activating ubiquitin-mediated proteolysis according to the BIOPEP database of bioactive peptides (ID 4005), the EROP-Moscow database Peptide inhibiting UBR protein according to the ChEMBL database the PubChem database Inhibitor of Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001) according to the AHTPDB database the BindingDB database the BIOPEP database of bioactive peptides (ID 7588) the BRENDA database the ChEMBL database the PubChem database Inhibitor of Bleomycin hydrolase (EC 3.4.22.40) (MEROPS ID: C01.084) according to the BRENDA database Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 420)
Additional Detail Fields 1 fields
2