Peptide record

TPDB48112

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Bitter Umami iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB48112
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Bitter Umami iDPPIV
Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
LA
Physicochemical Analysis
C9H18N2O3
RNDCEQGHIKMFPSTWYV
AL
202.25
6.02
0
0
2
-0
-0.73
2.800
245.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C9H18N2O3
202.25
6.02
-0
-0.73
2.800
202.2501
202.1313
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
310.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cushman D. W.
Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.) (1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.
1981
book

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)C)CC(C)C InChI=1S/C9H18N2O3/c1-5(2)4-7(10)8(12)11-6(3)9(13)14/h5-7H,4,10H2,1-3H3,(H,11,12)(H,13,14)/t6-,7-/m0/s1 InChIKey: HSQGMTRYSIHDAC-BQBZGAKWSA-N Activator of ubiquitin-mediated proteolysis according to the BIOPEP database of bioactive peptides (ID 4006) the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3175) the BRENDA database the EROP-Moscow database Inhibitor of Bleomycin hydrolase (EC 3.4.22.40) (MEROPS ID: C01.084) according to the BRENDA database Inhibitor of citrulline uptake in yeasts according to the ChEMBL database the PubChem database Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9499) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids the ChEMBL database the PubChem database
Evidence 2 Activity

Activity

IC50
Antihypertensive
310.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cushman D. W.
Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.) (1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.
1981
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)C)CC(C)C InChI=1S/C9H18N2O3/c1-5(2)4-7(10)8(12)11-6(3)9(13)14/h5-7H,4,10H2,1-3H3,(H,11,12)(H,13,14)/t6-,7-/m0/s1 InChIKey: HSQGMTRYSIHDAC-BQBZGAKWSA-N Activator of ubiquitin-mediated proteolysis according to the BIOPEP database of bioactive peptides (ID 4006) the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3175) the BRENDA database the EROP-Moscow database Inhibitor of Bleomycin hydrolase (EC 3.4.22.40) (MEROPS ID: C01.084) according to the BRENDA database Inhibitor of citrulline uptake in yeasts according to the ChEMBL database the PubChem database Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9499) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids the ChEMBL database the PubChem database
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Bella A. M., Erickson R. H. Jr., Kim Y. S.
Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV:kinetic properties and substrate specifities of the purified enzyme.Arch.Biochem.Biophys. 218 (1), 156-162
1982
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)C)CC(C)C InChI=1S/C9H18N2O3/c1-5(2)4-7(10)8(12)11-6(3)9(13)14/h5-7H,4,10H2,1-3H3,(H,11,12)(H,13,14)/t6-,7-/m0/s1 InChIKey: HSQGMTRYSIHDAC-BQBZGAKWSA-N Information concerning Dipeptidyl Peptidase IV (synonym: Dipeptidyl Aminopeptidase IV) (EC 3.4.14.5) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: S09.003 Another reference concerning peptide: Tulipano G., Sibilia V., Caroli A. M., Cocchi D., 2011, Whey proteins as source of dipeptidyl dipeptidase IV (dipeptidyl peptidase-4) inhibitors. Peptides, 32, 835-838 Activator of ubiquitin-mediated proteolysis according to the BIOPEP-UWM database of bioactive peptides (ID 4006) the EROP-Moscow database Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BindingDB database, the BIOPEP-UWM database of bioactive peptides (ID 7585) the ChEMBL database the PubChem database Inhibitor of Bleomycin hydrolase (EC 3.4.22.40) (MEROPS ID: C01.084) according to the BRENDA database Inhibitor of citrulline uptake in yeasts according to the ChEMBL database the PubChem database Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9499) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids the ChEMBL database the PubChem database
Additional Detail Fields 1 fields
2