TPDB

3D PDB MODEL

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TPDB ID TPDB48110

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

IYPR

FASTA

>TPDB48110|ACE inhibitors;Antihypertensive|length=4
IYPR

Formula C26H41N7O6

Absent Amino Acids ANDCEQGHLKMFSTWV

Common Amino Acids RIPY

Mass 547.65

PI 9.88

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 0.01

Hydrophobicity -0.725

Aliphatic Index 97.50

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 272.07

Polar Residues 1

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

4

Formula

C26H41N7O6

Mass

547.65

PI

9.88

Net Charge

+1

Boman Index

0.01

Hydrophobicity

-0.725

Chemical_Mass

547.6454

Monoisotopic_Mass

547.3109

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 10.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Saito Y., Wanezaki K., Kawato A., Imayasu S.

Title

Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci.Biotech.Biochem.58(10),1767-1771(1994)

Year 1994

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C26H41N7O6/c1-3-15(2)21(27)23(36)32-19(14-16-8-10-17(34)11-9-16)24(37)33-13-5-7-20(33)22(35)31-18(25(38)39)6-4-12-30-26(28)29/h8-11,15,18-21,34H,3-7,12-14,27H2,1-2H3,(H,31,35)(H,32,36)(H,38,39)(H4,28,29,30)/t15-,18-,19-,20-,21-/m0/s1 InChIKey=MHZTVIFHHVXFCG-JMMIECQRSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 10.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Saito Y., Wanezaki K., Kawato A., Imayasu S.

Title

Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci.Biotech.Biochem.58(10),1767-1771(1994)

Year 1994

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C26H41N7O6/c1-3-15(2)21(27)23(36)32-19(14-16-8-10-17(34)11-9-16)24(37)33-13-5-7-20(33)22(35)31-18(25(38)39)6-4-12-30-26(28)29/h8-11,15,18-21,34H,3-7,12-14,27H2,1-2H3,(H,31,35)(H,32,36)(H,38,39)(H4,28,29,30)/t15-,18-,19-,20-,21-/m0/s1 InChIKey=MHZTVIFHHVXFCG-JMMIECQRSA-N

Number_of_Residues

4