TPDB

3D PDB MODEL

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TPDB ID TPDB48109

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

YPRY

FASTA

>TPDB48109|ACE inhibitors;Antihypertensive|length=4
YPRY

Formula C29H39N7O7

Absent Amino Acids ANDCEQGHILKMFSTWV

Common Amino Acids Y

Mass 597.67

PI 9.63

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index -0.62

Hydrophobicity -2.175

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 498.60

Polar Residues 2

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

4

Formula

C29H39N7O7

Mass

597.67

PI

9.63

Net Charge

+1

Boman Index

-0.62

Hydrophobicity

-2.175

Chemical_Mass

597.6611

Monoisotopic_Mass

597.2902

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 17.40 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Saito Y., Wanezaki K., Kawato A., Imayasu S.

Title

Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci.Biotech.Biochem.58(10),1767-1771(1994)

Year 1994

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C29H39N7O7/c30-21(15-17-5-9-19(37)10-6-17)27(41)36-14-2-4-24(36)26(40)34-22(3-1-13-33-29(31)32)25(39)35-23(28(42)43)16-18-7-11-20(38)12-8-18/h5-12,21-24,37-38H,1-4,13-16,30H2,(H,34,40)(H,35,39)(H,42,43)(H4,31,32,33)/t21-,22-,23-,24-/m0/s1 InChIKey=BQRCCVQRJWIGGD-ZJZGAYNASA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 17.40 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Saito Y., Wanezaki K., Kawato A., Imayasu S.

Title

Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci.Biotech.Biochem.58(10),1767-1771(1994)

Year 1994

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C29H39N7O7/c30-21(15-17-5-9-19(37)10-6-17)27(41)36-14-2-4-24(36)26(40)34-22(3-1-13-33-29(31)32)25(39)35-23(28(42)43)16-18-7-11-20(38)12-8-18/h5-12,21-24,37-38H,1-4,13-16,30H2,(H,34,40)(H,35,39)(H,42,43)(H4,31,32,33)/t21-,22-,23-,24-/m0/s1 InChIKey=BQRCCVQRJWIGGD-ZJZGAYNASA-N

Number_of_Residues

4