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Peptide record

TPDB48108

ACE inhibitor ACE inhibitors Antihypertensive standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB48108
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
HGLF
Physicochemical Analysis
C23H32N6O5
ARNDCEQIKMPSTWYV
GHLF
472.54
7.85
1
0
2
+0
-0.72
0.750
97.50
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C23H32N6O5
472.54
7.85
+0
-0.72
0.750
472.5361
472.2427
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Mullally M. M., Meisel H., FitzGerald R. J.
Synthetic peptides corresponding to a-lactalbumin and a-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261
1996
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC1=CN=CN1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C23H32N6O5/c1-14(2)8-18(22(32)29-19(23(33)34)9-15-6-4-3-5-7-15)28-20(30)12-26-21(31)17(24)10-16-11-25-13-27-16/h3-7,11,13-14,17-19H,8-10,12,24H2,1-2H3,(H,25,27)(H,26,31)(H,28,30)(H,29,32)(H,33,34)/t17-,18-,19-/m0/s1 InChIKey=JOAGXTNVDXKNBJ-FHWLQOOXSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Mullally M. M., Meisel H., FitzGerald R. J.
Synthetic peptides corresponding to a-lactalbumin and a-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC1=CN=CN1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C23H32N6O5/c1-14(2)8-18(22(32)29-19(23(33)34)9-15-6-4-3-5-7-15)28-20(30)12-26-21(31)17(24)10-16-11-25-13-27-16/h3-7,11,13-14,17-19H,8-10,12,24H2,1-2H3,(H,25,27)(H,26,31)(H,28,30)(H,29,32)(H,33,34)/t17-,18-,19-/m0/s1 InChIKey=JOAGXTNVDXKNBJ-FHWLQOOXSA-N
Additional Detail Fields 1 fields
4