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Peptide record

TPDB48103

ACE inhibitor Ala-Val dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Bitter iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB48103
ACE inhibitor Ala-Val dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Bitter iDPPIV Selfassembly
Cardiometabolic peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
AV
Physicochemical Analysis
C8H16N2O3
RNDCEQGHILKMFPSTWY
AV
188.23
6.02
0
0
2
-0
-0.10
3.000
195.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
2
C8H16N2O3
188.23
6.02
-0
-0.10
3.000
188.2236
188.1157
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

26086903
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanorod Rod like Nanostructure
temperature: Room temperature solvent: Pyrimidine concentration: 2mg/ml
Selfassembly; Nanostructure=Nanorod; Rod like Nanostructure; Trigger=temperature: Room temperature; solvent: Pyrimidine; concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
Selfassembly
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
956.28 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Salampessy J., Reddy N., Kailasapathy K., Phillips M.
Functional and potential therapeutic ACE-inhibitory peptides derived from bromelain hydrolysis of trevally proteins. J. Funct. Foods 14, 716-725, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C8H16N2O3/c1-4(2)6(8(12)13)10-7(11)5(3)9/h4-6H,9H2,1-3H3,(H,10,11)(H,12,13)/t5-,6-/m0/s1 InChIKey=LIWMQSWFLXEGMA-WDSKDSINSA-N Alternative IC50 value 371.89 uM Salampessy J., Reddy N., Kailasapathy K., Phillips M. Functional and potential therapeutic ACE-inhibitory peptides derived from bromelain hydrolysis of trevally proteins. J. Funct. Foods, 2015, 14, 716-725 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to BIOPEP-UWM database of bioactive peptides (ID 8764)
Evidence 2 Activity

Activity

IC50
Antihypertensive
956.28 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Salampessy J., Reddy N., Kailasapathy K., Phillips M.
Functional and potential therapeutic ACE-inhibitory peptides derived from bromelain hydrolysis of trevally proteins. J. Funct. Foods 14, 716-725, 2015
2015
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C8H16N2O3/c1-4(2)6(8(12)13)10-7(11)5(3)9/h4-6H,9H2,1-3H3,(H,10,11)(H,12,13)/t5-,6-/m0/s1 InChIKey=LIWMQSWFLXEGMA-WDSKDSINSA-N Alternative IC50 value 371.89 uM Salampessy J., Reddy N., Kailasapathy K., Phillips M. Functional and potential therapeutic ACE-inhibitory peptides derived from bromelain hydrolysis of trevally proteins. J. Funct. Foods, 2015, 14, 716-725 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to BIOPEP-UWM database of bioactive peptides (ID 8764)
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C8H16N2O3/c1-4(2)6(8(12)13)10-7(11)5(3)9/h4-6H,9H2,1-3H3,(H,10,11)(H,12,13)/t5-,6-/m0/s1 InChIKey=LIWMQSWFLXEGMA-WDSKDSINSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BindingDB database the BIOPEP-UWM database of bioactive peptides (ID 8951) the ChEMBL database the DFBP database the EROP-Moscow database
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanorod Rod like Nanostructure Trigger=temperature: Room temperature solvent: Pyrimidine concentration: 2mg/ml
Nanorod Rod like Nanostructure

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Pyrimidine concentration: 2mg/ml
Scanning Electron Microscopy (SEM)
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
temperature: Room temperature solvent: Pyrimidine concentration: 2mg/ml
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
26086903
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly