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Peptide record

TPDB48093

ACE inhibitor from beta-CN ACE inhibitors Antihypertensive Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB48093
ACE inhibitor from beta-CN
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
PQR
Physicochemical Analysis
C16H29N7O5
ANDCEGHILKMFSTWYV
RQP
399.45
11.05
1
0
0
+1
1.84
-3.200
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C16H29N7O5
399.45
11.05
+1
1.84
-3.200
399.4442
399.2224
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
401.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Meisel H.
Casokinins as bioactive peptides in the primary strucure of casein. In: Food proteins, structure and functionality. ed. Schwenke K. D., Mothes R., VCh, Weinheim - New York - Basel - Cambridge - Tokyo, pp 67-75, 1993
1993
book

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCCNC(N)=N)(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1)C(O)=O InChI=1S/C16H29N7O5/c17-12(24)6-5-10(22-13(25)9-3-1-7-20-9)14(26)23-11(15(27)28)4-2-8-21-16(18)19/h9-11,20H,1-8H2,(H2,17,24)(H,22,25)(H,23,26)(H,27,28)(H4,18,19,21)/t9-,10-,11-/m0/s1 InChIKey=LSIWVWRUTKPXDS-DCAQKATOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111
Evidence 2 Activity

Activity

IC50
Antihypertensive
401.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Meisel H.
Casokinins as bioactive peptides in the primary strucure of casein. In: Food proteins, structure and functionality. ed. Schwenke K. D., Mothes R., VCh, Weinheim - New York - Basel - Cambridge - Tokyo, pp 67-75, 1993
1993
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCCNC(N)=N)(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1)C(O)=O InChI=1S/C16H29N7O5/c17-12(24)6-5-10(22-13(25)9-3-1-7-20-9)14(26)23-11(15(27)28)4-2-8-21-16(18)19/h9-11,20H,1-8H2,(H2,17,24)(H,22,25)(H,23,26)(H,27,28)(H4,18,19,21)/t9-,10-,11-/m0/s1 InChIKey=LSIWVWRUTKPXDS-DCAQKATOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111
Additional Detail Fields 1 fields
3