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Peptide record

TPDB48092

ACE inhibitor ACE inhibitors Antihypertensive standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB48092
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
PFPE
Physicochemical Analysis
C24H32N4O7
ARNDCQGHILKMSTWYV
P
488.54
3.29
0
1
1
-1
1.79
-0.975
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C24H32N4O7
488.54
3.29
-1
1.79
-0.975
488.5322
488.2263
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1000.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Meisel H.
Casokinins as bioactive peptides in the primary strucure of casein. In: Food proteins, structure and functionality ed Schwenke K.D., Mothes R., VCh, Weinheim - New York - Basel - Cambridge - Tokyo, pp 67-75, 1993
1993
book

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(O)=O)(NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]1([H])CCCN1)C(O)=O InChI=1S/C24H32N4O7/c29-20(30)11-10-17(24(34)35)26-22(32)19-9-5-13-28(19)23(33)18(14-15-6-2-1-3-7-15)27-21(31)16-8-4-12-25-16/h1-3,6-7,16-19,25H,4-5,8-14H2,(H,26,32)(H,27,31)(H,29,30)(H,34,35)/t16-,17-,18-,19-/m0/s1 InChIKey=MMRUTRDVOHJQBE-VJANTYMQSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
1000.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Meisel H.
Casokinins as bioactive peptides in the primary strucure of casein. In: Food proteins, structure and functionality ed Schwenke K.D., Mothes R., VCh, Weinheim - New York - Basel - Cambridge - Tokyo, pp 67-75, 1993
1993
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(O)=O)(NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]1([H])CCCN1)C(O)=O InChI=1S/C24H32N4O7/c29-20(30)11-10-17(24(34)35)26-22(32)19-9-5-13-28(19)23(33)18(14-15-6-2-1-3-7-15)27-21(31)16-8-4-12-25-16/h1-3,6-7,16-19,25H,4-5,8-14H2,(H,26,32)(H,27,31)(H,29,30)(H,34,35)/t16-,17-,18-,19-/m0/s1 InChIKey=MMRUTRDVOHJQBE-VJANTYMQSA-N
Additional Detail Fields 1 fields
4