TPDB

3D PDB MODEL

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TPDB ID TPDB48080

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

NILP

FASTA

>TPDB48080|ACE inhibitors;Antihypertensive|length=4
NILP

Formula C21H37N5O6

Absent Amino Acids ARDCEQGHKMFSTWYV

Common Amino Acids NILP

Mass 455.55

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -0.00

Hydrophobicity 0.800

Aliphatic Index 195.00

Half Life

Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

4

Formula

C21H37N5O6

Mass

455.55

PI

6.02

Net Charge

-0

Boman Index

-0.00

Hydrophobicity

0.800

Chemical_Mass

455.5469

Monoisotopic_Mass

455.2735

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 560.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem. 53, 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)CC(C)C)[C@H](CC)C)CC(=O)N InChI=1S/C21H37N5O6/c1-5-12(4)17(25-18(28)13(22)10-16(23)27)19(29)24-14(9-11(2)3)20(30)26-8-6-7-15(26)21(31)32/h11-15,17H,5-10,22H2,1-4H3,(H2,23,27)(H,24,29)(H,25,28)(H,31,32)/t12-,13-,14-,15-,17-/m0/s1 InChIKey: DHAAFQATDJILFL-BWJWTDLKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 560.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem. 53, 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)CC(C)C)[C@H](CC)C)CC(=O)N InChI=1S/C21H37N5O6/c1-5-12(4)17(25-18(28)13(22)10-16(23)27)19(29)24-14(9-11(2)3)20(30)26-8-6-7-15(26)21(31)32/h11-15,17H,5-10,22H2,1-4H3,(H2,23,27)(H,24,29)(H,25,28)(H,31,32)/t12-,13-,14-,15-,17-/m0/s1 InChIKey: DHAAFQATDJILFL-BWJWTDLKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001

Number_of_Residues

4