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Peptide record

TPDB48078

ACE inhibitors Antihypertensive standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB48078
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LSPA
Physicochemical Analysis
C17H30N4O6
RNDCEQGHIKMFTWYV
ALPS
386.45
6.02
0
0
2
-0
-0.15
0.800
122.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C17H30N4O6
386.45
6.02
-0
-0.15
0.800
386.4421
386.2158
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
315.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Yano S., Suzuki K., Funatsu G.
Isolation from alpha-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci.Biotech.Biochem. 60(4), 661-663 (1996)
1996
Journal

Other

4
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)O)C)CCC1)CO)CC(C)C InChI=1S/C17H30N4O6/c1-9(2)7-11(18)14(23)20-12(8-22)16(25)21-6-4-5-13(21)15(24)19-10(3)17(26)27/h9-13,22H,4-8,18H2,1-3H3,(H,19,24)(H,20,23)(H,26,27)/t10-,11-,12-,13-/m0/s1 InChIKey: YOAHEBWGKUOHCP-CYDGBPFRSA-N
Evidence 2 Activity

Activity

EC50
Antihypertensive
315.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Yano S., Suzuki K., Funatsu G.
Isolation from alpha-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci.Biotech.Biochem. 60(4), 661-663 (1996)
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)O)C)CCC1)CO)CC(C)C InChI=1S/C17H30N4O6/c1-9(2)7-11(18)14(23)20-12(8-22)16(25)21-6-4-5-13(21)15(24)19-10(3)17(26)27/h9-13,22H,4-8,18H2,1-3H3,(H,19,24)(H,20,23)(H,26,27)/t10-,11-,12-,13-/m0/s1 InChIKey: YOAHEBWGKUOHCP-CYDGBPFRSA-N
Additional Detail Fields 1 fields
4