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Peptide record

TPDB48076

ACE inhibitors Antihypertensive standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB48076
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LNPA
Physicochemical Analysis
C18H31N5O6
RDCEQGHIKMFSTWYV
ANLP
413.47
6.02
0
0
2
-0
0.14
0.125
122.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C18H31N5O6
413.47
6.02
-0
0.14
0.125
413.4674
413.2267
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
312.00 µM
ACE inhibitor
ah

Source & Reference

NA
Yano S., Suzuki K., Funatsu G.
Isolation from a-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci.Biotech.Biochem.60(4),661-663(1996)
1996
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C)C(O)=O InChI=1S/C18H31N5O6/c1-9(2)7-11(19)15(25)22-12(8-14(20)24)17(27)23-6-4-5-13(23)16(26)21-10(3)18(28)29/h9-13H,4-8,19H2,1-3H3,(H2,20,24)(H,21,26)(H,22,25)(H,28,29)/t10-,11-,12-,13-/m0/s1 InChIKey=PWBYMXCUFPVRNL-CYDGBPFRSA-N
Evidence 2 Activity

Activity

EC50
Antihypertensive
312.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Yano S., Suzuki K., Funatsu G.
Isolation from a-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci.Biotech.Biochem.60(4),661-663(1996)
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C)C(O)=O InChI=1S/C18H31N5O6/c1-9(2)7-11(19)15(25)22-12(8-14(20)24)17(27)23-6-4-5-13(23)16(26)21-10(3)18(28)29/h9-13H,4-8,19H2,1-3H3,(H2,20,24)(H,21,26)(H,22,25)(H,28,29)/t10-,11-,12-,13-/m0/s1 InChIKey=PWBYMXCUFPVRNL-CYDGBPFRSA-N
Additional Detail Fields 1 fields
4