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Peptide record

TPDB48072

ACE inhibitors Antihypertensive standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB48072
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
FYQQ
Physicochemical Analysis
C28H36N6O8
ARNDCEGHILKMPSTWV
Q
584.63
5.94
0
0
2
-0
-0.91
-1.375
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
254.86
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
4
C28H36N6O8
584.63
5.94
-0
-0.91
-1.375
584.6194
584.2586
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
25.00 µM
ACE inhibitor
ah

Source & Reference

NA
Yano S., Suzuki K., Funatsu G.
Isolation from a-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci.Biotech.Biochem.60(4),661-663(1996)
1996
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C28H36N6O8/c29-19(14-16-4-2-1-3-5-16)25(38)34-22(15-17-6-8-18(35)9-7-17)27(40)32-20(10-12-23(30)36)26(39)33-21(28(41)42)11-13-24(31)37/h1-9,19-22,35H,10-15,29H2,(H2,30,36)(H2,31,37)(H,32,40)(H,33,39)(H,34,38)(H,41,42)/t19-,20-,21-,22-/m0/s1 InChIKey=BJILEQBKPVGPRO-CMOCDZPBSA-N
Evidence 2 Activity

Activity

EC50
Antihypertensive
25.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Yano S., Suzuki K., Funatsu G.
Isolation from a-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci.Biotech.Biochem.60(4),661-663(1996)
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C28H36N6O8/c29-19(14-16-4-2-1-3-5-16)25(38)34-22(15-17-6-8-18(35)9-7-17)27(40)32-20(10-12-23(30)36)26(39)33-21(28(41)42)11-13-24(31)37/h1-9,19-22,35H,10-15,29H2,(H2,30,36)(H2,31,37)(H,32,40)(H,33,39)(H,34,38)(H,41,42)/t19-,20-,21-,22-/m0/s1 InChIKey=BJILEQBKPVGPRO-CMOCDZPBSA-N
Additional Detail Fields 1 fields
4