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Peptide record

TPDB48071

Name ACE inhibitor (from bovine alphas1-CN) ACE inhibitors Antihypertensive standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB48071
Name ACE inhibitor (from bovine alphas1-CN)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
FVAP
Physicochemical Analysis
C22H32N4O5
RNDCEQGHILKMSTWY
AFPV
432.52
6.02
0
0
3
-0
-0.78
1.800
97.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
4
C22H32N4O5
432.52
6.02
-0
-0.78
1.800
432.5120
432.2365
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
10.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Maruyama S., Nakagomi K., Tomizuka N., Suzuki H.
Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. Isolation and bradykinin-potentiating activity on the uterus. Agric. Biol. Chem., 49, 1405-1409 (1985)
1985
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N2[C@@H](CCC2)C(=O)O InChI=1S/C22H32N4O5/c1-13(2)18(25-19(27)16(23)12-15-8-5-4-6-9-15)20(28)24-14(3)21(29)26-11-7-10-17(26)22(30)31/h4-6,8-9,13-14,16-18H,7,10-12,23H2,1-3H3,(H,24,28)(H,25,27)(H,30,31)/t14-,16-,17-,18-/m0/s1 InChIKey=PTCUFGUAPHEYOL-DKIMLUQUSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
10.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Maruyama S., Nakagomi K., Tomizuka N., Suzuki H.
Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. Isolation and bradykinin-potentiating activity on the uterus. Agric. Biol. Chem., 49, 1405-1409 (1985)
1985
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N2[C@@H](CCC2)C(=O)O InChI=1S/C22H32N4O5/c1-13(2)18(25-19(27)16(23)12-15-8-5-4-6-9-15)20(28)24-14(3)21(29)26-11-7-10-17(26)22(30)31/h4-6,8-9,13-14,16-18H,7,10-12,23H2,1-3H3,(H,24,28)(H,25,27)(H,30,31)/t14-,16-,17-,18-/m0/s1 InChIKey=PTCUFGUAPHEYOL-DKIMLUQUSA-N
Additional Detail Fields 1 fields
4